Discovery of Spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as Potent NOP and Opioid Receptor Agonists (Q34063701)

25147602

30 July 2017

title

Discovery of Spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as Potent NOP and Opioid Receptor Agonists (English)

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30 July 2017

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12

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5 June 2020

author name string

Stefan Schunk

1

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5 June 2020

Klaus Linz

2

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Sven Frormann

3

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Claudia Hinze

4

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Stefan Oberbörsch

5

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Bernd Sundermann

6

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Saskia Zemolka

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Werner Englberger

8

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Tieno Germann

9

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Thomas Christoph

10

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Babette-Y Kögel

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Stephanie Harlfinger

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Derek Saunders

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Achim Kless

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Hans Schick

16

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Helmut Sonnenschein

17

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language of work or name

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24 June 2014

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25147602

ACS Medicinal Chemistry Letters

30 July 2017

published in

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volume

5

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issue

8

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page(s)

851-856

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The use of bifunctional NOP/mu and NOP receptor selective compounds for the treatment of pain, drug abuse, and psychiatric disorders.

5 June 2020

cites work

1 reference

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Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates

5 July 2018

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Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

5 July 2018

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(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties

5 July 2018

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Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

5 July 2018

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

5 July 2018

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Photocell measurements of rat motor activity. A contribution to sensitivity and variation in behavioral observations

5 July 2018

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An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

5 July 2018

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A preclinical comparison between different opioids: antinociceptive versus adverse effects

5 July 2018

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Antinociceptive properties of neurosteroids: a comparison of alphadolone and alphaxalone in potentiation of opioid antinociception

28 October 2018

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Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

28 October 2018

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4-Aryl-4-aminocyclohexanones and their derivatives, a novel class of analgesics. 3. m-Hydroxyphenyl derivatives

28 October 2018

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12 December 2020

4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring

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12 December 2020

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12 December 2020

The mouse jumping test--a simple screening method to estimate the physical dependence capacity of analgesics

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12 December 2020

4-Amino-4-arylcyclohexanones and their derivatives: a novel class of analgesics. 2. Modification of the carbonyl function

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12 December 2020

Frequency Dependence in the Action of the Class III Antiarrhythmic Drug Dofetilide Is Modulated by Altering L-Type Calcium Current and Digitalis Glucoside

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12 December 2020

Identifiers

DOI

10.1021/ML500116X

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5 June 2020

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5 June 2020

25147602

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