Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. (Q34062476)

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10 March 2020

title

Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors (English)

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5

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6

Shibo Jiang

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10 March 2020

7

Kuo-Hsiung Lee

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10 March 2020

author name string

Na Liu

1

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10 March 2020

Bingjie Qin

2

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10 March 2020

Lian-Qi Sun

3

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Fei Yu

4

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Lan Xie

8

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10 March 2020

language of work or name

English

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publication date

11 July 2014

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Bioorganic & Medicinal Chemistry Letters

10 March 2020

published in

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volume

24

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issue

16

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page(s)

3719-3723

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Structure-activity relationship studies on clinically relevant HIV-1 NNRTIs.

10 March 2020

cites work

1 reference

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Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.

5 July 2018

1 reference

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Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties

5 July 2018

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Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein

5 July 2018

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Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors

5 July 2018

1 reference

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Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

5 July 2018

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Design, Synthesis, and Evaluation of Diarylpyridines and Diarylanilines as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

5 July 2018

1 reference

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Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors

5 July 2018

1 reference

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Design and synthesis of orally bioavailable benzimidazoles as Raf kinase inhibitors

5 July 2018

1 reference

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Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.

5 July 2018

1 reference

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Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors

5 July 2018

1 reference

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Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase: from the Biology of Reverse Transcription to Molecular Design

5 July 2018

1 reference

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Molecular properties that influence the oral bioavailability of drug candidates

5 July 2018

1 reference

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Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective σ1 receptor ligands.

5 July 2018

1 reference

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A review of rilpivirine and elvitegravir resistance features and implications for treatment sequencing

28 October 2018

1 reference

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The influence of drug-like concepts on decision-making in medicinal chemistry

28 October 2018

1 reference

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The influence of lead discovery strategies on the properties of drug candidates

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25042339

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Impact of lipophilic efficiency on compound quality

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25042339

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMCL.2014.07.011

1 reference

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10 March 2020

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10 March 2020

PubMed publication ID

25042339

1 reference