Therapeutic potential of targeting the oncogenic SHP2 phosphatase (Q34061302)

30 July 2017

title

Therapeutic potential of targeting the oncogenic SHP2 phosphatase. (English)

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30 July 2017

Li-Fan Zeng

1

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30 July 2017

Ruo-Yu Zhang

2

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30 July 2017

Zhi-Hong Yu

3

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30 July 2017

Sijiu Li

4

1 reference

30 July 2017

Li Wu

5

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30 July 2017

Andrea M Gunawan

6

1 reference

30 July 2017

Brandon S Lane

7

1 reference

30 July 2017

Raghuveer S Mali

8

1 reference

30 July 2017

Xingjun Li

9

1 reference

30 July 2017

Rebecca J Chan

10

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30 July 2017

Reuben Kapur

11

1 reference

30 July 2017

Clark D Wells

12

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30 July 2017

Zhong-Yin Zhang

13

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30 July 2017

language of work or name

English

0 references

publication date

28 July 2014

1 reference

Journal of Medicinal Chemistry

30 July 2017

published in

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30 July 2017

volume

57

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30 July 2017

issue

15

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30 July 2017

page(s)

6863-6609

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The somatic genomic landscape of glioblastoma

30 July 2017

cites work

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

28 July 2018

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Discovery of a novel shp2 protein tyrosine phosphatase inhibitor

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design

28 July 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

28 July 2018

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Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

28 July 2018

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Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.

28 July 2018

1 reference

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Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

28 July 2018

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28 July 2018

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Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold

28 October 2018

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28 October 2018

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28 October 2018

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Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.

28 October 2018

1 reference

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28 October 2018

1 reference

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28 October 2018

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28 October 2018

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28 October 2018

1 reference

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28 October 2018

1 reference

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Large-scale structural analysis of the classical human protein tyrosine phosphatome

28 October 2018

1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

28 October 2018

1 reference

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2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action

28 October 2018

1 reference

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Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds

28 October 2018

1 reference

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

28 October 2018

1 reference

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Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.

28 October 2018

1 reference

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PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group

28 October 2018

1 reference

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Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

28 October 2018

1 reference

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Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136714

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136714

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

28 October 2018

1 reference

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Tyrosine kinases as targets for cancer therapy

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25003231

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25003231

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM5006176

1 reference

30 July 2017

1 reference

30 July 2017

1 reference