Drug-target residence time: critical information for lead optimization. (Q34054343)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20663707 AND SRC:MED&resulttype=core&format=json

8 February 2020

review article

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title

Drug-target residence time: critical information for lead optimization (English)

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8 February 2020

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2

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8 February 2020

author name string

Hao Lu

series ordinal

1

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8 February 2020

publication date

19 July 2010

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Current Opinion in Chemical Biology

8 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20663707 AND SRC:MED&resulttype=core&format=json

8 February 2020

volume

14

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8 February 2020

issue

4

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8 February 2020

page(s)

467-474

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20663707 AND SRC:MED&resulttype=core&format=json

A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis

8 February 2020

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The importance of drug-target residence time.

5 July 2018

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5 July 2018

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Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

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Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis : Residence Time and in Vivo Activity

5 July 2018

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Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant

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5 July 2018

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Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases

5 July 2018

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Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background

5 July 2018

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Residence time of receptor-ligand complexes and its effect on biological function

5 July 2018

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Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

5 July 2018

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5 July 2018

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Drug-target residence time and its implications for lead optimization

5 July 2018

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5 July 2018

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Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118).

5 July 2018

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Antimetastatic activity of a novel mechanism-based gelatinase inhibitor

5 July 2018

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5 July 2018

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Can the pharmaceutical industry reduce attrition rates?

5 July 2018

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The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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28 October 2018

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28 October 2018

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28 October 2018

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The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

28 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20663707

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20663707

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The role of binding kinetics in therapeutically useful drug action

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20663707

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CBPA.2010.06.176

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20663707 AND SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20663707 AND SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

20663707

1 reference