A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. (Q34051627)

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English	A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.	scientific article

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2 February 2020

A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells (English)

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2 February 2020

Orthoebolavirus zairense

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Rachel Kaletsky

3

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2 February 2020

7

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2 February 2020

10

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2 February 2020

author name string

Parag P Shah

1

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2 February 2020

Tianhua Wang

2

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2 February 2020

Michael C Myers

4

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2 February 2020

Jeremy E Purvis

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2 February 2020

Huiyan Jing

6

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2 February 2020

Doron C Greenbaum

8

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2 February 2020

Amos B Smith

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2 February 2020

Scott L Diamond

11

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2 February 2020

publication date

13 May 2010

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2 February 2020

Molecular Pharmacology

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2 February 2020

78

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2 February 2020

2

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2 February 2020

319-324

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2 February 2020

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

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5 July 2018

Molecular docking of cathepsin L inhibitors in the binding site of papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor

1 reference

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5 July 2018

Cysteine cathepsin proteases as pharmacological targets in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity

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5 July 2018

Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

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5 July 2018

Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein

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5 July 2018

SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Cathepsin L is involved in proteolytic processing of the Hendra virus fusion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Ebola virus: from discovery to vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

Lysosomal cysteine proteases (cathepsins): promising drug targets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917856

5 July 2018

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

1 reference

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5 July 2018

Lysosomal cysteine proteases: facts and opportunities

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5 July 2018

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

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5 July 2018

The lysosomal cysteine proteases

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5 July 2018

Emerging roles for cysteine proteases in human biology

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5 July 2018

Comprehensive search for cysteine cathepsins in the human genome

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28 October 2018

Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.

1 reference

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28 October 2018

Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy

1 reference

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28 October 2018

Breakthrough of the year. SARS: a pandemic prevented

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28 October 2018

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

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12 December 2020

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10.1124/MOL.110.064261

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2 February 2020

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2 February 2020

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2 February 2020

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