Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers. (Q34040808)

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12 October 2019

title

Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers (English)

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12 October 2019

author name string

Ellis J

1

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12 October 2019

Talbot D

2

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12 October 2019

Dillon N

3

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12 October 2019

Grosveld F

4

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12 October 2019

language of work or name

English

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publication date

1 January 1993

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12 October 2019

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12 October 2019

volume

12

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12 October 2019

issue

1

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12 October 2019

page(s)

127-134

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Tissue-specific in vitro transcription from the mouse albumin promoter

12 October 2019

cites work

1 reference

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Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns.

5 July 2018

1 reference

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Position-independent, high-level expression of the human beta-globin gene in transgenic mice

5 July 2018

1 reference

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Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

5 July 2018

1 reference

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A dominant control region from the human beta-globin locus conferring integration site-independent gene expression

5 July 2018

1 reference

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The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.

5 July 2018

1 reference

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Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Molecular analysis of the human beta-globin locus activation region

5 July 2018

1 reference

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An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes

5 July 2018

1 reference

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The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression

5 July 2018

1 reference

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Detailed analysis of the site 3 region of the human beta-globin dominant control region

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

The beta-globin dominant control region: hypersensitive site 2

5 July 2018

1 reference

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A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer

5 July 2018

1 reference

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Activity and tissue-specific expression of the transcription factor NF-E1 multigene family

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Synergistic enhancement of globin gene expression by activator protein-1-like proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Hypersensitive site 4 of the human beta globin locus control region

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

In vivo protein-DNA interactions at the beta-globin gene locus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Protein-DNA interactions in vivo of an erythroid-specific, human beta-globin locus enhancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Recombinant 43-kDa USF binds to DNA and activates transcription in a manner indistinguishable from that of natural 43/44-kDa USF.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

The 5'HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Importance of globin gene order for correct developmental expression.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Human gamma- to beta-globin gene switching in transgenic mice.

5 July 2018

1 reference

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Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413182

Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions

5 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8428573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8428573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8428573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/J.1460-2075.1993.TB05638.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8428573 AND SRC:MED&resulttype=core&format=json

12 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8428573 AND SRC:MED&resulttype=core&format=json

12 October 2019

PubMed publication ID

8428573

1 reference