Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues (Q34025368)

30 July 2017

title

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues (English)

1 reference

30 July 2017

8

Jan Vijg

1 reference

30 July 2017

Ekaterina Nekhaeva

1

1 reference

30 July 2017

Natalya D Bodyak

2

1 reference

30 July 2017

Yevgenya Kraytsberg

3

1 reference

30 July 2017

Sean B McGrath

4

1 reference

30 July 2017

Nathalie J Van Orsouw

5

1 reference

30 July 2017

Anna Pluzhnikov

6

1 reference

30 July 2017

Jeanne Y Wei

7

1 reference

30 July 2017

Konstantin Khrapko

9

1 reference

30 July 2017

language of work or name

English

0 references

publication date

9 April 2002

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

1 reference

30 July 2017

volume

99

1 reference

30 July 2017

issue

8

1 reference

30 July 2017

page(s)

5521-5526

1 reference

Aging: a theory based on free radical and radiation chemistry

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Mutational fingerprints of aging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Facile detection of mitochondrial DNA mutations in tumors and bodily fluids

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Applications of constant denaturant capillary electrophoresis/high-fidelity polymerase chain reaction to human genetic analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Somatic mutations of the mitochondrial genome in human colorectal tumours

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: evidence for mismatch repair systems in mitochondrial genome.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Ancient mtDNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Apparent mtDNA heteroplasmy in Alzheimer’s disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Mitochondrial mutational spectra in human cells and tissues

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

A proposed refinement of the mitochondrial free radical theory of aging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Homopolymeric tract heteroplasmy in mtDNA from tissues and single oocytes: support for a genetic bottleneck

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Evolutionary trail of the mitochondrial genome as based on human 16S rDNA pseudogenes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Sequence and organization of the human mitochondrial genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

The biologic clock: the mitochondria?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.072670199

Multi-copy nuclear pseudogenes of mitochondrial DNA reveal recent acute genetic changes in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.072670199

A nuclear 'fossil' of the mitochondrial D-loop and the origin of modern humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.072670199

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.072670199

A Survey of Exact Inference for Contingency Tables

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.072670199

Human mitochondria: distinct organelles or dynamic network?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.072670199

Mammalian mitochondrial D-loop region structural analysis: identification of new conserved sequences and their functional and evolutionary implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.072670199

Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

Apparent Turnover of Mitochondrial Deoxyribonucleic Acid and Mitochondrial Phospholipids in the Tissues of the Rat

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122802

An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region

29 October 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.072670199

Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma

21 January 2018

1 reference

12 December 2020

Nuclear and mitochondrial genome instability in human breast cancer

1 reference

12 December 2020

Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis

1 reference

12 December 2020

Quantification and sequencing of somatic deleted mtDNA in single cells: evidence for partially duplicated mtDNA in aged human tissues

1 reference

12 December 2020

Two distinct types of mitochondrial DNA segregation in mouse-rat hybrid cells. Stochastic segregation and chromosome-dependent segregation

1 reference

12 December 2020

Mutations of mitochondrial DNA and human death

1 reference

12 December 2020

Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly

1 reference

12 December 2020

High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

1 reference

12 December 2020

Detection and analysis of mitochondrial DNA and RNA in muscle by in situ hybridization and single-fiber PCR

1 reference

12 December 2020

Detection of somatic mutations in the mitochondrial DNA control region of colorectal and gastric tumors by heteroduplex and single-strand conformation analysis

1 reference

12 December 2020

Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle

1 reference

12 December 2020

Mutational scanning of mitochondrial DNA by two-dimensional electrophoresis

1 reference

12 December 2020

Frameshift mutagenesis by eucaryotic DNA polymerases in vitro

1 reference

12 December 2020

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.072670199

1 reference

release_ye5zvcofxreznjz3qwl5iu4gou

30 July 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ye5zvcofxreznjz3qwl5iu4gou

24 November 2022

mapped directly with Wikidata item

PMC publication ID

122802

1 reference

30 July 2017

1 reference