Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement (Q34016697)

24816556

30 July 2017

title

Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement (English)

1 reference

30 July 2017

0 references

1 August 2014

1 reference

30 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24816556 AND SRC:MED&resulttype=core&format=json

2 June 2020

volume

59

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24816556 AND SRC:MED&resulttype=core&format=json

2 June 2020

issue

1-3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24816556 AND SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

23-34

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24816556 AND SRC:MED&resulttype=core&format=json

CD28 and CD3 have complementary roles in T-cell traction forces

2 June 2020

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5 July 2018

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Non-catalytic functions of Pyk2 and Fyn regulate late stage adhesion in human T cells

5 July 2018

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The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.

5 July 2018

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5 July 2018

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F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

5 July 2018

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Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells

5 July 2018

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5 July 2018

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Integrin inside-out signaling and the immunological synapse

5 July 2018

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Transcriptional control of T-cell development

5 July 2018

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Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling

5 July 2018

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New insights into the T cell synapse from single molecule techniques

5 July 2018

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Focal adhesion kinase: exploring Fak structure to gain insight into function

5 July 2018

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Multifaceted regulation of T cells by CD44

5 July 2018

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Shaping the T‐cell repertoire: a matter of life and death

5 July 2018

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The FERM domain: organizing the structure and function of FAK.

5 July 2018

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Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate

5 July 2018

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Mediation of T-cell activation by actin meshworks

5 July 2018

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Regulation of the Tyrosine Kinase Pyk2 by Calcium Is through Production of Reactive Oxygen Species in Cytotoxic T Lymphocytes

5 July 2018

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Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

5 July 2018

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T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.

5 July 2018

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Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

5 July 2018

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The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems

5 July 2018

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An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages

5 July 2018

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5 July 2018

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A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction

5 July 2018

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Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

5 July 2018

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Structural basis for the interaction between focal adhesion kinase and CD4

5 July 2018

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Dual function of focal adhesion kinase in regulating integrin-induced MMP-2 and MMP-9 release by human T lymphoid cells

5 July 2018

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Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function

5 July 2018

1 reference

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Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells

5 July 2018

1 reference

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Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration

5 July 2018

1 reference

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The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Proline-rich tyrosine kinase 2 and Rac activation by chemokine and integrin receptors controls NK cell transendothelial migration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

MIP-1alpha induces activation of phosphatidylinositol-3 kinase that associates with Pyk-2 and is necessary for B-cell migration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Regulation of Pyk2 expression by p56(Lck) in Jurkat T lymphocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing

5 July 2018

1 reference

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Beta 1-integrin-mediated cell signaling in T lymphocytes

5 July 2018

1 reference

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The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells

5 July 2018

1 reference

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Characterization of the Novel Focal Adhesion Kinase RAFTK in Hematopoietic Cells

5 July 2018

1 reference

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T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

5 July 2018

1 reference

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Role of the VLA-4 molecule in T cell costimulation. Identification of the tyrosine phosphorylation pattern induced by the ligation of VLA-4.

5 July 2018

1 reference

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Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

5 July 2018

1 reference

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T lymphocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading

5 July 2018

1 reference

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Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src

5 July 2018

1 reference

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

5 July 2018

1 reference

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T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4 T lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling

5 July 2018

1 reference

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CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45.

21 January 2018

1 reference

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Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

21 January 2018

1 reference

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Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

Hypophosphorylated and inactive Pyk2 associates with paxillin at the microtubule organizing center in hematopoietic cells.

21 January 2018

1 reference

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Pyk2 cytonuclear localization: mechanisms and regulation by serine dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

The Phosphatase PTP-PEST Promotes Secondary T Cell Responses by Dephosphorylating the Protein Tyrosine Kinase Pyk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

Lymphocyte function-associated antigen-1-mediated T cell adhesion is impaired by low molecular weight phosphotyrosine phosphatase-dependent inhibition of FAK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12026-014-8527-Y

LFA-1 integrin and the microtubular cytoskeleton are involved in the Ca(2)( )-mediated regulation of the activity of the tyrosine kinase PYK2 in T cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125427

p59fyn-p125FAK cooperation in development of CD4 CD8 thymocytes

29 October 2018

1 reference

12 December 2020

CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells

1 reference

12 December 2020

CD44-mediated elongated T cell spreading requires Pyk2 activation by Src family kinases, extracellular calcium, phospholipase C and phosphatidylinositol-3 kinase

1 reference

12 December 2020

Beta2-integrin, LFA-1, and TCR/CD3 synergistically induce tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)) in PHA-activated T cells

1 reference

12 December 2020

T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2

1 reference

12 December 2020

Fibronectin induces phosphorylation of a 120-kDa protein and synergizes with the T cell receptor to activate cytotoxic T cell clones

1 reference

12 December 2020

Alpha 4 beta 1 (CD49d/CD29) integrin costimulation of human T cells enhances transcription factor and cytokine induction in the absence of altered sensitivity to anti-CD3 stimulation

1 reference

12 December 2020

Cutting edge: functional role for proline-rich tyrosine kinase 2 in NK cell-mediated natural cytotoxicity

1 reference

12 December 2020

Focal adhesion kinase (pp125FAK) is tyrosine phosphorylated after engagement of alpha 4 beta 1 and alpha 5 beta 1 integrins on human T-lymphoblastic cells

1 reference

12 December 2020

Pyk2 is differentially regulated by beta1 integrin- and CD28-mediated co-stimulation in human CD4 T lymphocytes

1 reference

12 December 2020

Cytotoxic T lymphocytes express a beta3 integrin which can induce the phosphorylation of focal adhesion kinase and the related PYK-2

1 reference

12 December 2020

A critical role for p59fyn in CD2-based signal transduction

1 reference

12 December 2020

10.1007/S12026-014-8527-Y

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24816556 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 June 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24816556 AND SRC:MED&resulttype=core&format=json

2 June 2020

24816556

1 reference