Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. (Q34007710)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24991765 AND SRC:MED&resulttype=core&format=json

21 March 2020

title

Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin (English)

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21 March 2020

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3

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21 March 2020

author name string

R A Charan

1

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21 March 2020

B N Johnson

2

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21 March 2020

J D Nardozzi

4

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21 March 2020

M J LaVoie

5

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21 March 2020

publication date

3 July 2014

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21 March 2020

published in

Cell Death and Disease

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21 March 2020

volume

5

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21 March 2020

page(s)

e1313

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Creative Commons Attribution 3.0 Unported

21 March 2020

copyright license

start time

1 July 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

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Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

5 July 2018

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Structure of the human Parkin ligase domain in an autoinhibited state

5 July 2018

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Structure of parkin reveals mechanisms for ubiquitin ligase activation

5 July 2018

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Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity.

5 July 2018

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The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

5 July 2018

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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

5 July 2018

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The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

5 July 2018

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Multiple functions of BCL-2 family proteins

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Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons

5 July 2018

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Parkin promotes degradation of the mitochondrial pro-apoptotic ARTS protein

5 July 2018

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The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

5 July 2018

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PINK1- and Parkin-mediated mitophagy at a glance

5 July 2018

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Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

5 July 2018

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Proteostasis and Movement Disorders: Parkinson's Disease and Amyotrophic Lateral Sclerosis

5 July 2018

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Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

5 July 2018

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Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission.

5 July 2018

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Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

5 July 2018

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Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

5 July 2018

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Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease

5 July 2018

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BAX supports the mitochondrial network, promoting bioenergetics in nonapoptotic cells

5 July 2018

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Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

5 July 2018

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Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization.

5 July 2018

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Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

5 July 2018

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Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming

5 July 2018

1 reference

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

5 July 2018

1 reference

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IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation

5 July 2018

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

5 July 2018

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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

5 July 2018

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Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

5 July 2018

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Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps

5 July 2018

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

5 July 2018

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A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

5 July 2018

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Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

5 July 2018

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Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

5 July 2018

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Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model

5 July 2018

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Dopamine covalently modifies and functionally inactivates parkin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

5 July 2018

1 reference

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3

5 July 2018

1 reference

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Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Structure of Bax: coregulation of dimer formation and intracellular localization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Conformation of the Bax C-terminus regulates subcellular location and cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Regulated targeting of BAX to mitochondria.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Bax directly induces release of cytochrome c from isolated mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123072

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons

5 July 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

Involvement of the N-terminus of Bax in its intracellular localization and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

Cell death and apoptosis regulating proteins in Parkinson's disease--a cautionary note

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

BAX protein-immunoreactivity in midbrain neurons of Parkinson’s disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

Paraquat neurotoxicity is mediated by a Bak-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

High-yield isolation of murine microglia by mild trypsinization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDDIS.2014.278

Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24991765

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aberrant Folding of Pathogenic Parkin Mutants

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24991765

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2014.278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24991765 AND SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24991765 AND SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

24991765

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24991765 AND SRC:MED&resulttype=core&format=json