KCNQ2/KCNQ3 K channels and the molecular pathogenesis of epilepsy: implications for therapy (Q34001959)

30 July 2017

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title

KCNQ2/KCNQ3 K channels and the molecular pathogenesis of epilepsy: implications for therapy (English)

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30 July 2017

Rogawski MA

1

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30 July 2017

language of work or name

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1 September 2000

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30 July 2017

published in

Trends in Neurosciences

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30 July 2017

volume

23

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30 July 2017

issue

9

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30 July 2017

page(s)

393-398

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Benign familial neonatal convulsions linked to genetic markers on chromosome 20.

30 July 2017

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A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

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A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family

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Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K channels causes epilepsy

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Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy

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Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice

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KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel

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Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K( ) channels that underlie the neuronal M current

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KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness

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KCNQ4, a K channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.

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A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy

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Deletion of the K(V)1.1 potassium channel causes epilepsy in mice

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Developmental seizure susceptibility of kv1.1 potassium channel knockout mice

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Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K channel GIRK2

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Novel KCNQ1 and HERG missense mutations in Dutch long-QT families

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MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

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Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS 2

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7 January 2021

Treatment of myotonia with antiarrhythmic drugs

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Different effects of mexiletine on two mutant sodium channels causing paramyotonia congenita and hyperkalemic periodic paralysis

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Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na channel blockade and to increases in heart rate. Implications for gene-specific therapy.

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Improvement of repolarization abnormalities by a K channel opener in the LQT1 form of congenital long-QT syndrome

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Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium

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7 January 2021

The anticonvulsant retigabine potently suppresses epileptiform discharges in the low Ca and low Mg model in the hippocampal slice preparation.

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Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex hippocampal slices.

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7 January 2021

The new anticonvulsant retigabine (D-23129) acts as an opener of K channels in neuronal cells

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7 January 2021

Characterization of the K channel opening effect of the anticonvulsant retigabine in PC12 cells

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7 January 2021

The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits

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7 January 2021

Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine

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7 January 2021

10.1016/S0166-2236(00)01629-5

Identifiers

DOI

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30 July 2017

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