Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells (Q33998266)

30 July 2017

title

Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells (English)

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30 July 2017

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Joel T Adler

3

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Muthusamy Kunnimalaiyaan

object named as

Muthusamy Kunnimalaiyaan

6

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author name string

David Yu Greenblatt

1

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30 July 2017

Max A Cayo

2

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30 July 2017

Li Ning

4

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30 July 2017

Megan R Haymart

5

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30 July 2017

Herbert Chen

7

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30 July 2017

language of work or name

English

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publication date

1 June 2008

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30 July 2017

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30 July 2017

volume

247

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30 July 2017

issue

6

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30 July 2017

page(s)

1036-1040

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Palliation of advanced thyroid malignancies

30 July 2017

cites work

1 reference

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Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells

5 July 2018

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5 July 2018

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Multiple Molecular pathways explain the anti-proliferative effect of valproic acid on prostate cancer cells in vitro and in vivo

5 July 2018

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5 July 2018

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Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice

5 July 2018

1 reference

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Valproic acid induces apoptosis, p16INK4A upregulation and sensitization to chemotherapy in human melanoma cells

5 July 2018

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Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B

5 July 2018

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Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells

5 July 2018

1 reference

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Valproic acid induces apoptosis in prostate carcinoma cell lines by activation of multiple death pathways

5 July 2018

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Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation

5 July 2018

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Experimental study on the mechanism of the apoptosis of leukemic cells induced by valproic acid

5 July 2018

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Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC.

5 July 2018

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Hairy Enhancer of Split-1 (HES-1), a Notch1 effector, inhibits the growth of carcinoid tumor cells

5 July 2018

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Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells

5 July 2018

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Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells

5 July 2018

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Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1

5 July 2018

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ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells

5 July 2018

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Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling

5 July 2018

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Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells.

5 July 2018

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Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway

5 July 2018

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5 July 2018

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5 July 2018

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Notch signaling induces rapid degradation of achaete-scute homolog 1.

5 July 2018

1 reference

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Notch signaling induces cell cycle arrest in small cell lung cancer cells

5 July 2018

1 reference

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

5 July 2018

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Histone deacetylases, transcriptional control, and cancer

5 July 2018

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Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection

5 July 2018

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Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells.

5 July 2018

1 reference

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The effects of the histone deacetylase inhibitor valproic acid on cell cycle, growth suppression and apoptosis in multiple myeloma.

29 October 2018

1 reference

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Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904809

Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18520232

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Initial lymph node dissection increases cure rates in patients with medullary thyroid cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18520232

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18520232

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1097/SLA.0B013E3181758D0E

1 reference

30 July 2017

1 reference

30 July 2017

1 reference