Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat (Q33997420)

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English	Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat	scientific article

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Europe PubMed Central

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30 July 2017

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat (English)

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30 July 2017

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10 June 2020

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10 June 2020

Tomáš Cihlář

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Tomas Cihlar

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10 June 2020

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Eve-Irene Lepist

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10 June 2020

Xuexiang Zhang

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10 June 2020

Jia Hao

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10 June 2020

Jane Huang

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10 June 2020

Alan Kosaka

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10 June 2020

Bernard P Murray

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10 June 2020

Roy Bannister

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10 June 2020

Yong Huang

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10 June 2020

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19 March 2014

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30 July 2017

Kidney International

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10 June 2020

86

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10 June 2020

2

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10 June 2020

350-357

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10 June 2020

Renal transporters in drug development

1 reference

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In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.

1 reference

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28 July 2018

A phase 1 study to evaluate the effect of dolutegravir on renal function via measurement of iohexol and para-aminohippurate clearance in healthy subjects

1 reference

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28 July 2018

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1 reference

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1 reference

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Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients

1 reference

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Prediction of fluoroquinolone-induced elevation in serum creatinine levels: a case of drug-endogenous substance interaction involving the inhibition of renal secretion.

1 reference

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28 July 2018

Major contribution of tubular secretion to creatinine clearance in mice.

1 reference

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Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H( )-organic cation antiporters

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Lack of effect of DX-619, a novel des-fluoro(6)-quinolone, on glomerular filtration rate measured by serum clearance of cold iohexol

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DEPRESSION OF THE EXOGENOUS CREATININE/INULIN OR THIOSULFATE CLEARANCE RATIOS IN MAN BY DIODRAST AND p-AMINOHIPPURIC ACID.

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28 July 2018

Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney

1 reference

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Effects of moderate-dose versus high-dose trimethoprim on serum creatinine and creatinine clearance and adverse reactions

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28 July 2018

Pyrimethamine inhibits renal secretion of creatinine

1 reference

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Creatinine elevation in patients receiving amiodarone correlates with serum amiodarone concentration

1 reference

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28 July 2018

Serum creatinine and renal function

1 reference

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28 July 2018

Evaluation of "true" creatinine clearance in rats reveals extensive renal secretion

1 reference

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28 July 2018

Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.

1 reference

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29 October 2018

Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, d

1 reference

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29 October 2018

Effect of cobicistat on glomerular filtration rate in subjects with normal and impaired renal function.

1 reference

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29 October 2018

A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.

1 reference

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Randomized, phase 2 evaluation of two single-tablet regimens elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate for the initial treatment of HIV infection

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12 December 2020

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Tubular excretion of creatinine in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/24646860

12 December 2020

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1 reference

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1 reference

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1 reference

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1 reference

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Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs

1 reference

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12 December 2020

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Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidn

1 reference

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12 December 2020

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10.1038/KI.2014.66

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10 June 2020

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10 June 2020

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10 June 2020

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