The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. (Q33995918)

30 July 2017

title

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. (English)

1 reference

30 July 2017

R K Slany

1

1 reference

30 July 2017

C Lavau

series ordinal

2

1 reference

30 July 2017

M L Cleary

series ordinal

3

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 January 1998

1 reference

Molecular and Cellular Biology

30 July 2017

published in

1 reference

30 July 2017

volume

18

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30 July 2017

issue

1

1 reference

30 July 2017

page(s)

122-129

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Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

30 July 2017

cites work

1 reference

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MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).

5 July 2018

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A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins

5 July 2018

1 reference

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The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures

5 July 2018

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An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro

5 July 2018

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Disruption of a homolog of trithorax by 11q23 translocations: leukemogenic and transcriptional implications.

5 July 2018

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Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation.

5 July 2018

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5 July 2018

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An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

5 July 2018

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TFG/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9.

5 July 2018

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Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia

5 July 2018

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An RNA polymerase II elongation factor encoded by the human ELL gene

5 July 2018

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The mixed lineage leukemia (MLL) protein involved in 11q23 translocations contains a domain that binds cruciform DNA and scaffold attachment region (SAR) DNA.

5 July 2018

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Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs

5 July 2018

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MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13.

5 July 2018

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Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases

5 July 2018

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HMG domain proteins: architectural elements in the assembly of nucleoprotein structures

5 July 2018

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Transcriptional activation of Drosophila homeotic genes from distant regulatory elements

5 July 2018

1 reference

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ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells

5 July 2018

1 reference

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ALL-1 partial duplication in acute leukemia

5 July 2018

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TFIIF-TAF-RNA polymerase II connection

5 July 2018

1 reference

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A nuclear protein with sequence similarity to proteins implicated in human acute leukemias is important for cellular morphogenesis and actin cytoskeletal function in Saccharomyces cerevisiae

5 July 2018

1 reference

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Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each.

5 July 2018

1 reference

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Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours

5 July 2018

1 reference

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Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains

5 July 2018

1 reference

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Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations.

5 July 2018

1 reference

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Altered Hox expression and segmental identity in Mll-mutant mice

5 July 2018

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Unidirectional digestion with exonuclease III in DNA sequence analysis

5 July 2018

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A vector for expressing GAL4(1-147) fusions in mammalian cells

5 July 2018

1 reference

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Translocations, master genes, and differences between the origins of acute and chronic leukemias

5 July 2018

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Oncogenic conversion of transcription factors by chromosomal translocations

5 July 2018

1 reference

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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure

5 July 2018

1 reference

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Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain

5 July 2018

1 reference

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Isolation and characterization of the cDNA encoding human DNA methyltransferase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

Versatile retroviral vectors for potential use in gene therapy

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

A specific deletion in the breakpoint cluster region of the ALL-1 gene is associated with acute lymphoblastic T-cell leukemias

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121463

The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9418860

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cytogenetic profile of 109 lipomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9418860

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9418860

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.18.1.122

1 reference

30 July 2017

1 reference

30 July 2017

1 reference