Structure of tau protein and assembly into paired helical filaments (Q33971326)

30 July 2017

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title

Structure of tau protein and assembly into paired helical filaments (English)

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30 July 2017

3

E M Mandelkow

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30 July 2017

P Friedhoff

1

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30 July 2017

M von Bergen

series ordinal

2

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30 July 2017

E Mandelkow

series ordinal

4

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30 July 2017

language of work or name

English

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publication date

1 July 2000

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Biochimica et Biophysica Acta

30 July 2017

published in

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30 July 2017

volume

1502

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30 July 2017

issue

1

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30 July 2017

page(s)

122-132

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Molecular genetics of Alzheimer's disease

30 July 2017

cites work

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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Tau protein pathology in neurodegenerative diseases

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Neuropathological stageing of Alzheimer-related changes

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Correlations of synaptic and pathological markers with cognition of the elderly

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Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories: Concurrences and Cautions

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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7 January 2021

Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease.

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7 January 2021

Increased cerebrospinal fluid tau in patients with Alzheimer's disease

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7 January 2021

Biochemical diagnostic markers to detect early Alzheimer's disease

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7 January 2021

Tau protein function in living cells

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7 January 2021

The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau

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7 January 2021

Tau complexes with phospholipase C-gamma in situ

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7 January 2021

Microtubule-associated protein 2c reorganizes both microtubules and microfilaments into distinct cytological structures in an actin-binding protein-280-deficient melanoma cell line

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

A spatial gradient of tau protein phosphorylation in nascent axons.

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7 January 2021

The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains

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7 January 2021

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

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7 January 2021

Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.

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7 January 2021

Association of mitogen-activated protein kinase with the microtubule cytoskeleton

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7 January 2021

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

The pool of map kinase associated with microtubules is small but constitutively active

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Tau in Alzheimer's disease.

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

A protein factor essential for microtubule assembly

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Structure and novel exons of the human tau gene

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

The primary structure and heterogeneity of tau protein from mouse brain

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Primary structure of high molecular weight tau present in the peripheral nervous system

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Tau protein binds to microtubules through a flexible array of distributed weak sites

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Domains of tau protein and interactions with microtubules

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Straight and paired helical filaments in Alzheimer disease have a common structural unit

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation

1 reference

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7 January 2021

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Aberrant neurofilament phosphorylation in Alzheimer disease

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Tau gene mutation in familial progressive subcortical gliosis

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Epitopes that span the tau molecule are shared with paired helical filaments.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Specific pathological Tau protein variants characterize Pick's disease.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

The carboxyl third of tau is tightly bound to paired helical filaments.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Structural stability of paired helical filaments requires microtubule-binding domains of Tau: A model for self-association

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

The relation of the properties of Congo red-stained amyloid fibrils to the -conformation

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Peptides from the Conserved Ends of the Rod Domain of Desmin Disassemble Intermediate Filaments and Reveal Unexpected Structural Features: A Circular Dichroism, Fourier Transform Infrared, and Electron Microscopic Study

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Tau factor polymers are similar to paired helical filaments of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Isoforms of tau protein from mammalian brain and avian erythrocytes: structure, self-assembly, and elasticity

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Polymerization of Microtubule-associated Protein Tau under Near-physiological Conditions

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

RNA sequestration to pathological lesions of neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

A nucleated assembly mechanism of Alzheimer paired helical filaments

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

A kinetic model for amyloid formation in the prion diseases: importance of seeding

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Molecular evolution of tau protein: implications for Alzheimer's disease.

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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https://api.crossref.org/works/10.1016/S0925-4439(00)50038-7

7 January 2021

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

1 reference

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7 January 2021

10.1016/S0925-4439(00)00038-7

Identifiers

DOI

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30 July 2017

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