Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism (Q33965102)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513808 AND SRC:MED&resulttype=core&format=json

4 February 2020

review article

1 reference

title

Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513808 AND SRC:MED&resulttype=core&format=json

4 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513808 AND SRC:MED&resulttype=core&format=json

4 February 2020

author name string

Hai Yan

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513808 AND SRC:MED&resulttype=core&format=json

4 February 2020

language of work or name

English

0 references

publication date

31 May 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513808 AND SRC:MED&resulttype=core&format=json

4 February 2020

number of pages

10

1 reference

Journal of the National Cancer Institute

inferred from page(s)

published in

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4 February 2020

volume

102

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4 February 2020

issue

13

1 reference

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4 February 2020

page(s)

932-941

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513808 AND SRC:MED&resulttype=core&format=json

IDH1 and IDH2: not your typical oncogenes

4 February 2020

cites work

1 reference

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

5 July 2018

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The prognostic IDH1( R132 ) mutation is associated with reduced NADP -dependent IDH activity in glioblastoma

5 July 2018

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Evidence for genetic heterogeneity in D-2-hydroxyglutaric aciduria

5 July 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

5 July 2018

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Genetic alterations and signaling pathways in the evolution of gliomas

5 July 2018

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Recurring mutations found by sequencing an acute myeloid leukemia genome

5 July 2018

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Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

5 July 2018

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IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas

5 July 2018

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

5 July 2018

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Glutathionylation regulates cytosolic NADP -dependent isocitrate dehydrogenase activity

5 July 2018

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IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

5 July 2018

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Metabolic enzymes as oncogenes or tumor suppressors

5 July 2018

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IDH1 and IDH2 mutations in gliomas

5 July 2018

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IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors

5 July 2018

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Analysis of the IDH1 codon 132 mutation in brain tumors

5 July 2018

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Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle

5 July 2018

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An integrated genomic analysis of human glioblastoma multiforme

5 July 2018

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An SOD mimic protects NADP -dependent isocitrate dehydrogenase against oxidative inactivation.

5 July 2018

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Comparative proteomic analysis of brains of naturally aging mice

5 July 2018

1 reference

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Ethanol induces peroxynitrite-mediated toxicity through inactivation of NADP -dependent isocitrate dehydrogenase and superoxide dismutase

5 July 2018

1 reference

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Molecular pathology of malignant gliomas

5 July 2018

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Novel insights into L-2-hydroxyglutaric aciduria: mass isotopomer studies reveal 2-oxoglutaric acid as the metabolic precursor of L-2-hydroxyglutaric acid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Small interfering RNA-mediated silencing of mitochondrial NADP -dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and anticancer drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

The tricarboxylic acid cycle, an ancient metabolic network with a novel twist

5 July 2018

1 reference

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The 2007 WHO classification of tumours of the central nervous system

5 July 2018

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The consensus coding sequences of human breast and colorectal cancers

5 July 2018

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A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

5 July 2018

1 reference

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Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

5 July 2018

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Thioredoxin and its related molecules: update 2005.

5 July 2018

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Modulation of NADP( )-dependent isocitrate dehydrogenase in aging.

5 July 2018

1 reference

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Role of NADP -dependent isocitrate dehydrogenase (NADP -ICDH) on cellular defence against oxidative injury by gamma-rays

5 July 2018

1 reference

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Glycation-induced inactivation of NADP( )-dependent isocitrate dehydrogenase: implications for diabetes and aging

5 July 2018

1 reference

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Regulation of high glucose-induced apoptosis by mitochondrial NADP -dependent isocitrate dehydrogenase

5 July 2018

1 reference

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5 July 2018

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Cytosolic NADP -dependent isocitrate dehydrogenase plays a key role in lipid metabolism

5 July 2018

1 reference

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Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

5 July 2018

1 reference

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Inactivation of NADP -dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells

5 July 2018

1 reference

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Inactivation of NADP( )-dependent isocitrate dehydrogenase by nitric oxide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Crystal structure of porcine mitochondrial NADP -dependent isocitrate dehydrogenase complexed with Mn2 and isocitrate. Insights into the enzyme mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Cytosolic NADP( )-dependent isocitrate dehydrogenase status modulates oxidative damage to cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Cellular defense against UVB-induced phototoxicity by cytosolic NADP( )-dependent isocitrate dehydrogenase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

The human PICD gene encodes a cytoplasmic and peroxisomal NADP( )-dependent isocitrate dehydrogenase

5 July 2018

1 reference

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Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family

5 July 2018

1 reference

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IDP3 Encodes a Peroxisomal NADP-dependent Isocitrate Dehydrogenase Required for the β-Oxidation of Unsaturated Fatty Acids

5 July 2018

1 reference

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Peroxisomal beta -oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions

5 July 2018

1 reference

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Expression and Mutagenesis of Mammalian Cytosolic NADP -Specific Isocitrate Dehydrogenase

5 July 2018

1 reference

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Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation

5 July 2018

1 reference

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Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria

5 July 2018

1 reference

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Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases.

5 July 2018

1 reference

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Cytosolic NADP( )-dependent isocitrate dehydrogenase. Isolation of rat cDNA and study of tissue-specific and developmental expression of mRNA

5 July 2018

1 reference

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Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Phosphorylation inactivates Escherichia coli isocitrate dehydrogenase by preventing isocitrate binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Electrostatic and steric contributions to regulation at the active site of isocitrate dehydrogenase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Regulation of an enzyme by phosphorylation at the active site

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Localization of cytosolic NADP-dependent isocitrate dehydrogenase in the peroxisomes of rat liver cells: biochemical and immunocytochemical studies.

5 July 2018

1 reference

Kinetic mechanism of Escherichia coli isocitrate dehydrogenase.

21 January 2018

1 reference

Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP -dependent isocitrate dehydrogenase.

21 January 2018

1 reference

Silencing of mitochondrial NADP -dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis

21 January 2018

1 reference

Reverse flux through cardiac NADP( )-isocitrate dehydrogenase under normoxia and ischemia

21 January 2018

1 reference

Dependence of peroxisomal beta-oxidation on cytosolic sources of NADPH.

21 January 2018

1 reference

Silencing of cytosolic NADP( )-dependent isocitrate dehydrogenase by small interfering RNA enhances the sensitivity of HeLa cells toward staurosporine

21 January 2018

1 reference

Inactivation of NADP -dependent isocitrate dehydrogenase by lipid peroxidation products

21 January 2018

1 reference

Inactivation of mitochondrial NADP -dependent isocitrate dehydrogenase by hypochlorous acid

21 January 2018

1 reference

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

21 January 2018

1 reference

Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

21 January 2018

1 reference

Absence of IDH2 codon 172 mutation in common human cancers.

21 January 2018

1 reference

Taxing sugar-sweetened beverages

21 January 2018

1 reference

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

21 January 2018

1 reference

IDH1 and IDH2 mutations in gliomas.

21 January 2018

1 reference

IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas

21 January 2018

1 reference

Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome

21 January 2018

1 reference

L-2-hydroxyglutaric aciduria and brain tumors in children with mutations in the L2HGDH gene: neuroimaging findings

21 January 2018

1 reference

IDH1 mutations in gliomas: when an enzyme loses its grip

21 January 2018

1 reference

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

21 January 2018

1 reference

Inactivation of NADP( )-dependent isocitrate dehydrogenase by singlet oxygen derived from photoactivated rose bengal

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Inactivation of NADP( )-dependent isocitrate dehydrogenase by reactive oxygen species

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2897878

Multiple NADPH-producing pathways control glutathione (GSH) content in retina

29 October 2018

1 reference

12 December 2020

Regulation of singlet oxygen-induced apoptosis by cytosolic NADP -dependent isocitrate dehydrogenase

1 reference

12 December 2020

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion

1 reference

12 December 2020

Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms

1 reference

12 December 2020

Identification by mutagenesis of arginines in the substrate binding site of the porcine NADP-dependent isocitrate dehydrogenase

1 reference

12 December 2020

Identifiers

DOI

10.1093/JNCI/DJQ187

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513808 AND SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513808 AND SRC:MED&resulttype=core&format=json

4 February 2020

PubMed publication ID

20513808

1 reference