Functional expression and localization of P-glycoprotein at the blood brain barrier (Q33960099)

30 July 2017

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title

Functional expression and localization of P-glycoprotein at the blood brain barrier (English)

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30 July 2017

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Reina Bendayan

1

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30 July 2017

Gloria Lee

series ordinal

2

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30 July 2017

Moise Bendayan

series ordinal

3

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30 July 2017

publication date

1 June 2002

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Microscopy Research and Technique

30 July 2017

published in

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30 July 2017

volume

57

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30 July 2017

issue

5

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30 July 2017

page(s)

365-380

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Transporting therapeutics across the blood-brain barrier

30 July 2017

cites work

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Differential modulation of P-glycoprotein transport by protein kinase inhibition

21 January 2018

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P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

21 January 2018

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Polarity of the Blood-Brain Barrier: Neutral Amino Acid Transport into Isolated Brain Capillaries

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Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals

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Isolated Brain Microvessels: A Purified, Metabolically Active Preparation from Bovine Cerebral Cortex

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Transcytosis of macromolecules through the blood-brain barrier: a cell biological perspective and critical appraisal

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Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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Independent blood-brain barrier transport systems for nucleic acid precursors

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The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

21 January 2018

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Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes.

21 January 2018

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Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

21 January 2018

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Detection of P glycoprotein activity on normal and leukemic CD34 cells.

21 January 2018

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Nitric oxide and endothelin secretion by brain microvessel endothelial cells: Regulation by cyclic nucleotides

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The P-glycoprotein multidrug transporter

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Expression of a multidrug-resistance gene in human tumors and tissues

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Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4).

21 January 2018

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Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes.

21 January 2018

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P-Glycoprotein on astrocyte foot processes of unfixed isolated human brain capillaries

21 January 2018

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Isolation of metabolically active capillaries from rat brain1,2

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Biochemistry of multidrug resistance mediated by the multidrug transporter

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Isolation and expression of a complementary DNA that confers multidrug resistance

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A comparative study on the uptake and subsequent decarboxylation of monoamine precursors in cerebral microvessels

21 January 2018

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Is the multidrug transporter a flippase?

21 January 2018

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mRna expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting

21 January 2018

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Characterization of transferrin receptor in an immortalized cell line of rat brain endothelial cells, RBE4.

21 January 2018

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High levels of P-glycoprotein detected in isolated brain capillaries

21 January 2018

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

21 January 2018

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Cerebral and pial microvessels: differential expression of gamma-glutamyl transpeptidase and alkaline phosphatase

21 January 2018

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Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

21 January 2018

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Role of P-glycoprotein in the renal transport of dideoxynucleoside analog drugs

21 January 2018

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Multidrug resistance: molecular mechanisms and clinical relevance

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Reduced permeability in CHO cells as a mechanism of resistance to colchicine

21 January 2018

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Phosphorylation of the multidrug resistance associated glycoprotein.

21 January 2018

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Bovine brain endothelial cells express tight junctions and monoamine oxidase activity in long-term culture.

21 January 2018

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The Susceptibility of Cerebral Endothelial Cells to Astroglial Induction of Blood-Brain Barrier Enzymes Depends on Their Proliferative State

21 January 2018

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Potential mechanisms of the age-related changes in the blood-brain barrier

21 January 2018

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Isolation of brain capillaries: a simplified technique

21 January 2018

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Monoclonal antibodies specific for P-glycoprotein

21 January 2018

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Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate

21 January 2018

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Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

21 January 2018

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Fine structural localization of a blood-brain barrier to exogenous peroxidase

21 January 2018

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Glucose transport in immortalized rat brain capillary endothelial cells in vitro: transport activity and GLUT1 expression

21 January 2018

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Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter

21 January 2018

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Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

21 January 2018

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Multidrug resistance: molecular biology and clinical relevance.

21 January 2018

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Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells

21 January 2018

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Phosphatidylcholine translocase: a physiological role for the mdr2 gene

21 January 2018

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Barrier mechanisms in the brain, I. Adult brain.

21 January 2018

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The physiological function of drug-transporting P-glycoproteins

21 January 2018

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 January 2018

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Functional intracellular P-glycoprotein

21 January 2018

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The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?

21 January 2018

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Induction of blood-brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors

21 January 2018

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Morphological and functional characterization of an in vitro blood-brain barrier model

21 January 2018

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Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord

21 January 2018

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Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions.

21 January 2018

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

21 January 2018

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P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

21 January 2018

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Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

21 January 2018

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Mapping of phenytoin-inducible cytochrome P450 immunoreactivity in the mouse central nervous system

21 January 2018

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Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells

21 January 2018

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P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JEMT.10090

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30 July 2017

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