Suppression of Ras-induced apoptosis by the Rac GTPase (Q33959056)

30 July 2017

title

Suppression of Ras-induced apoptosis by the Rac GTPase (English)

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30 July 2017

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T Joneson

1

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30 July 2017

D Bar-Sagi

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

1 September 1999

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Molecular and Cellular Biology

30 July 2017

published in

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30 July 2017

volume

19

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30 July 2017

issue

9

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30 July 2017

page(s)

5892-5901

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describes a project that uses

30 July 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC84438/fullTextXML

inferred from PubMed Central ID database lookup

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

A Rac1 effector site controlling mitogenesis through superoxide production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Ras signalling and apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues

5 July 2018

1 reference

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Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

5 July 2018

1 reference

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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

5 July 2018

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

5 July 2018

1 reference

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Ras effectors and their role in mitogenesis and oncogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

5 July 2018

1 reference

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Identification and characterization of an IkappaB kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

5 July 2018

1 reference

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Activate NF-kappa B or die?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

5 July 2018

1 reference

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The cat and mouse games that genes, viruses, and cells play

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

PI3K: downstream AKTion blocks apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

5 July 2018

1 reference

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Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

The NF-kappa B and I kappa B proteins: new discoveries and insights

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

A role for Rho in Ras transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

The stress-activated protein kinase subfamily of c-Jun kinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Multiple Ras functions can contribute to mammalian cell transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

NF-kappa B: a lesson in family values

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Overexpression of mos oncogene product in Swiss 3T3 cells induces apoptosis preferentially during S-phase.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-kappa B.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

The p21 ras C-terminus is required for transformation and membrane association

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Ras promotes cell survival in Drosophila by downregulating hid expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Increasing complexity of Ras signaling.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84438

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

29 October 2018

1 reference

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An essential role for Rac in Ras transformation

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EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

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PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

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12 December 2020

Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65

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The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

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Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo

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Identifiers

DOI

10.1128/MCB.19.9.5892

1 reference

30 July 2017

1 reference

30 July 2017

1 reference