Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells (Q33949133)

25068121

30 July 2017

title

Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells (English)

1 reference

30 July 2017

1 reference

10

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31 May 2020

Rebeca Dieguez-Gonzalez

5

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31 May 2020

Julie Magarian Blander

9

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31 May 2020

author name string

Pauline Rimmelé

1

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31 May 2020

Carolina L Bigarella

2

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31 May 2020

Raymond Liang

3

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31 May 2020

Brigitte Izac

4

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31 May 2020

Gaetan Barbet

6

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31 May 2020

Michael Donovan

7

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Carlo Brugnara

8

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31 May 2020

Saghi Ghaffari

11

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31 May 2020

publication date

6 June 2014

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30 July 2017

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31 May 2020

volume

3

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31 May 2020

issue

1

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31 May 2020

page(s)

44-59

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The NAD( )/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

31 May 2020

cites work

1 reference

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Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance

28 July 2018

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SIRT3 reverses aging-associated degeneration

28 July 2018

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FOXOs: signalling integrators for homeostasis maintenance

28 July 2018

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FOXO transcription factors throughout T cell biology

28 July 2018

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

28 July 2018

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Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

28 July 2018

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Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib

28 July 2018

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Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

28 July 2018

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Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

28 July 2018

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AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

28 July 2018

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FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

28 July 2018

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Franklin H. Epstein Lecture: Sirtuins, aging, and medicine

28 July 2018

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Manifestations and mechanisms of stem cell aging.

28 July 2018

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ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice.

28 July 2018

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mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.

28 July 2018

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Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

28 July 2018

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Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

28 July 2018

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TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

28 July 2018

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Mammalian sirtuins: biological insights and disease relevance

28 July 2018

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FoxO3 regulates neural stem cell homeostasis

28 July 2018

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Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution

28 July 2018

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A functional screen to identify novel effectors of hematopoietic stem cell activity

28 July 2018

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FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging

28 July 2018

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SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization

28 July 2018

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Hematopoietic stem cell aging and self-renewal

28 July 2018

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Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation

28 July 2018

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Foxo3 is required for the regulation of oxidative stress in erythropoiesis

28 July 2018

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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

28 July 2018

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Hematopoietic stem cell aging: mechanism and consequence.

28 July 2018

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The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.

28 July 2018

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Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

28 July 2018

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SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity

28 July 2018

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

28 July 2018

1 reference

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28 July 2018

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

28 July 2018

1 reference

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Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor

28 July 2018

1 reference

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

28 July 2018

1 reference

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Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

28 July 2018

1 reference

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Essential and instructive roles of GATA factors in eosinophil development

28 July 2018

1 reference

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Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

Age-associated characteristics of murine hematopoietic stem cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

The aging of hematopoietic stem cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

Long-term erythropoietic repopulating ability of old, young, and fetal stem cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

Regulation and Function of FoxO Transcription Factors in Normal and Cancer Stem Cells: What Have We Learned?

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

CD4 CD25high Foxp3 regulatory T cells in myelodysplastic syndrome (MDS).

29 October 2018

1 reference

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29 October 2018

1 reference

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Cell intrinsic alterations underlie hematopoietic stem cell aging.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

Differentiation of B lymphocytes from hematopoietic stem cells.

29 October 2018

1 reference

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Mammalian SIRT1 represses forkhead transcription factors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

Stem cell repopulation efficiency but not pool size is governed by p27(kip1).

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110778

10.1016/J.STEMCR.2014.04.015

29 October 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25068121 AND SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25068121 AND SRC:MED&resulttype=core&format=json

31 May 2020

25068121

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25068121 AND SRC:MED&resulttype=core&format=json