Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation (Q33948297)

30 July 2017

title

Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation (English)

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30 July 2017

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S Aznar

1

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30 July 2017

P F Valerón

2

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30 July 2017

S V del Rincon

3

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30 July 2017

L F Pérez

4

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30 July 2017

R Perona

5

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30 July 2017

J C Lacal

6

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30 July 2017

language of work or name

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1 October 2001

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Molecular Biology of the Cell

30 July 2017

published in

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30 July 2017

volume

12

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30 July 2017

issue

10

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30 July 2017

page(s)

3282-3294

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Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors

30 July 2017

cites work

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Regulation of STAT3 by direct binding to the Rac1 GTPase

5 July 2018

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The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation

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5 July 2018

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Serine phosphorylation and negative regulation of Stat3 by JNK

5 July 2018

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Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.

5 July 2018

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Stat protein transactivation domains recruit p300/CBP through widely divergent sequences

5 July 2018

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5 July 2018

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5 July 2018

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Creation of human tumour cells with defined genetic elements

5 July 2018

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Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation

5 July 2018

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Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

5 July 2018

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ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases

5 July 2018

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STATs as mediators of cytokine-induced responses

5 July 2018

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STAT3 is required for the gp130-mediated full activation of the c-myc gene

5 July 2018

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Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)

5 July 2018

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Activation of Stat3 by v-Src is through a Ras-independent pathway

5 July 2018

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Interleukin-1 beta and reactive oxygen species mediate activation of c-Jun NH2-terminal kinases, in human epithelial cells, by two independent pathways

5 July 2018

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Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation

5 July 2018

1 reference

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Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases

5 July 2018

1 reference

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Activation of STAT transcription factors in oncogenic tyrosine kinase signaling

5 July 2018

1 reference

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Rho proteins induce metastatic properties in vivo

5 July 2018

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STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

5 July 2018

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Association of Stat3-Dependent Transcriptional Activation of p19INK4Dwith IL-6-Induced Growth Arrest

5 July 2018

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Rho GTPases and signaling networks

5 July 2018

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STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727.

5 July 2018

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STATs and Gene Regulation

5 July 2018

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Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid‐dependent signaling

5 July 2018

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A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

5 July 2018

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Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

5 July 2018

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Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

5 July 2018

1 reference

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A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras-Rac pathway.

5 July 2018

1 reference

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Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

5 July 2018

1 reference

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The small GTPase Rho: cellular functions and signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Activation and association of Stat3 with Src in v-Src-transformed cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Insulin stimulates the serine phosphorylation of the signal transducer and activator of transcription (STAT3) isoform

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

A role for Rho in Ras transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Tumorigenic activity of rho genes from Aplysia californica

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

An essential role for Rac in Ras transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

Rho GTPases are over-expressed in human tumors.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

STATs as activators of apoptosis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60173

A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

29 October 2018

1 reference

12 December 2020

Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

1 reference

12 December 2020

Signal Transducer and Activator of Transcription-3 Serine Phosphorylation by Insulin Is Mediated by a Ras/Raf/MEK-Dependent Pathway*

1 reference

12 December 2020

Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases

1 reference

12 December 2020

Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors

1 reference

12 December 2020

Involvement of RhoA and its interaction with protein kinase C and Src in CCK-stimulated pancreatic acini

1 reference

12 December 2020

Lack of c-Jun activity increases survival to cisplatin

1 reference

12 December 2020

Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

1 reference

12 December 2020

Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts

1 reference

12 December 2020

Identifiers

DOI

10.1091/MBC.12.10.3282

1 reference

30 July 2017

1 reference

30 July 2017

1 reference