Methodological advances in drug discovery for Chagas disease (Q33945347)

30 July 2017

title

Methodological advances in drug discovery for Chagas disease (English)

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30 July 2017

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Rick L Tarleton

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author name string

Juan M Bustamante

series ordinal

1

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30 July 2017

language of work or name

English

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publication date

1 June 2011

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Expert Opinion on Drug Discovery

30 July 2017

published in

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30 July 2017

volume

6

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30 July 2017

issue

6

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30 July 2017

page(s)

653-661

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Trypanocidal activity of aziridinyl nitrobenzamide prodrugs

30 July 2017

cites work

1 reference

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Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease

28 July 2018

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Cellular analysis of host cell infection by different developmental stages of Trypanosoma cruzi

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Eliminating Chagas disease: challenges and a roadmap

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Neglected disease research and development: how much are we really spending?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8 T cells in chronic Chagas disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Bioluminescent imaging of Trypanosoma cruzi infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Drug-induced cure drives conversion to a stable and protective CD8 T central memory response in chronic Chagas disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

The challenges of Chagas Disease-- grim outlook or glimmer of hope

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Etiological treatment of chronic Chagas disease: neglected 'evidence' by evidence-based medicine

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Bioluminescent assays for high-throughput screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

In vitro and in vivo activity of lignan lactones derivatives against Trypanosoma cruzi

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Development of resazurin microtiter assay for drug sensibility testing of Trypanosoma cruzi epimastigotes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Expression of fluorescent genes in Trypanosoma cruzi and Trypanosoma rangeli (Kinetoplastida: Trypanosomatidae): its application to parasite-vector biology.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

28 July 2018

Chagas' disease and AIDS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Central memory and effector memory T cell subsets: function, generation, and maintenance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

High content screening applied to large-scale cell biology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

A critical review on Chagas disease chemotherapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

The Alamar Blue® assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Use of Toxoplasma gondii expressing beta-galactosidase for colorimetric assessment of drug activity in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Effect of allopurinol on Trypanosoma cruzi: metabolism and biological activity in intracellular and bloodstream forms

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Screening in vitro of natural products against blood forms of Trypanosoma cruzi

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Setting of a colorimetric method to determine the viability of Trypanosoma cruzi epimastigotes

28 July 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

A new pharmacological screening assay with Trypanosoma cruzi epimastigotes expressing beta-galactosidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

Synthesis and antiparasitic properties of new 4-N-benzylamino-4-hetarylbut-1-enes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

Escherichia coli beta-galactosidase as an in vitro and in vivo reporter enzyme and stable transfection marker in the intracellular protozoan parasite Toxoplasma gondii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

Reporter genes facilitating discovery of drugs targeting protozoan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

Cell culture and animal infection with distinct Trypanosoma cruzi strains expressing red and green fluorescent proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

Follow-up of 18 patients with human immunodeficiency virus infection and chronic Chagas' disease, with reactivation of Chagas' disease causing cardiac disease in three patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

New method for quantification of Trypanosoma cruzi in animal's tissue in the chronic phase of experimental Chagas' disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.2011.573782

The treatment of Chagas disease (South American trypanosomiasis)

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial

10 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease

10 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection

10 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Treatment of chronic Chagas' disease with benznidazole: clinical and serologic evolution of patients with long-term follow-up

10 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

Fatal meningoencephalitis caused by reactivation of Trypanosoma cruzi infection in a patient with AIDS

10 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122921

1,2-dioxetanes: novel chemiluminescent enzyme substrates. Applications to immunoassays

10 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21712965

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1517/17460441.2011.573782

1 reference

30 July 2017

1 reference

30 July 2017

1 reference