GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke (Q33943541)

30 July 2017

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title

GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke (English)

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30 July 2017

Green AR

1

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30 July 2017

Hainsworth AH

series ordinal

2

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30 July 2017

Jackson DM

series ordinal

3

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30 July 2017

publication date

1 July 2000

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30 July 2017

number of pages

12

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based on heuristic

inferred from page(s)

published in

Neuropharmacology

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30 July 2017

volume

39

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30 July 2017

issue

9

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30 July 2017

page(s)

1483-1494

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Elevated gamma-aminobutyric acid levels attenuate the metabolic response to bilateral ischemia

30 July 2017

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Epidemiology of stroke

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Selective chromatolysis of neurons in the gerbil brain: a possible consequence of "epileptic" activity produced by common carotid artery occlusion

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Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR.

7 January 2021

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From GABAA receptor diversity emerges a unified vision of GABAergic inhibition

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Chlormethiazole antagonises seizures induced by N-methyl-DL-aspartate without interacting with the NMDA receptor complex.

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7 January 2021

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Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer

7 January 2021

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MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

7 January 2021

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Glutamate as a candidate retrograde messenger at interneurone-Purkinje cell synapses of rat cerebellum

7 January 2021

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Clomethiazole (Zendra) in acute ischemic stroke: basic pharmacology and biochemistry and clinical efficacy

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Attenuation by chlormethiazole of oedema following focal ischaemia in the cerebral cortex of the rat.

7 January 2021

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A simple intravenous infusion method in rodents for determining the potency of anticonvulsants acting through GABAergic mechanisms

7 January 2021

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The immediate consequences of middle cerebral artery occlusion on GABA synthesis in mouse cortex and cerebellum

7 January 2021

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The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: evidence for the protective effect of chlormethiazole

7 January 2021

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Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion

7 January 2021

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Inhibition of GABA release from slices prepared from several brain regions of rats at various times following a convulsion

7 January 2021

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An investigation of the possible interaction of clomethiazole with glutamate and ion channel sites as an explanation of its neuroprotective activity

7 January 2021

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A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor

7 January 2021

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Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments

7 January 2021

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Modulation of GABAA and glycine receptors by chlormethiazole

7 January 2021

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Two distinct interactions of barbiturates and chlormethiazole with the GABAA receptor complex in rat cuneate nucleus in vitro

7 January 2021

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Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?

7 January 2021

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Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus

7 January 2021

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Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors

7 January 2021

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High Dose Baclofen Is Neuroprotective but Also Causes Intracerebral Hemorrhage: A Quantal Bioassay Study Using the Intraluminal Suture Occlusion Method

7 January 2021

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Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells

7 January 2021

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Inhibition in postischemic rat hippocampus: GABA receptors, GABA release, and inhibitory postsynaptic potentials

7 January 2021

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A dendritic GABAA-mediated IPSP regulates facilitation of NMDA-mediated responses to burst stimulation of afferent fibers in piriform cortex

7 January 2021

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Intracerebral human microdialysis. In vivo study of an acute focal ischemic model of the human brain

7 January 2021

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Does neuroprotection improve stroke outcome?

7 January 2021

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Effects of clomethiazole on radial-arm maze performance following global forebrain ischemia in gerbils

7 January 2021

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Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits

7 January 2021

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Combination therapy protects ischemic brain in rats. A glutamate antagonist plus a gamma-aminobutyric acid agonist

7 January 2021

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Combination Chemotherapy Extends the Therapeutic Window to 60 Minutes After Stroke

7 January 2021

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Effect of ganaxolone in a rodent model of cerebral hematoma

7 January 2021

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Presynaptic ionotropic receptors and the control of transmitter release.

7 January 2021

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The attenuation of kainate-induced neurotoxicity by chlormethiazole and its enhancement by dizocilpine, muscimol, and adenosine receptor agonists

7 January 2021

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New models of focal cerebral ischaemia

7 January 2021

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Effect of gamma-aminobutyric acid modulation on neuronal ischemia in rabbits

7 January 2021

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GABA concentrations in the striatum following repetitive cerebral ischemia

7 January 2021

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Pharmacological modulation of GABA(A) receptor-mediated postsynaptic potentials in the CA1 region of the rat hippocampus

7 January 2021

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Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species.

7 January 2021

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Modulation of inhibitory synapses in the mammalian brain

7 January 2021

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https://api.crossref.org/works/10.1016/S0028-3908(99)00233-6

An update on GABAA receptors

7 January 2021

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https://api.crossref.org/works/10.1016/S0028-3908(99)00233-6

Chlormethiazole: neurochemical actions at the gamma-aminobutyric acid receptor complex

7 January 2021

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https://api.crossref.org/works/10.1016/S0028-3908(99)00233-6

Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1.

7 January 2021

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Neuroprotection for acute stroke: making clinical trials work

7 January 2021

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Preservation of GABAergic perikarya and boutons after transient ischemia in the gerbil hippocampal CA1 field.

7 January 2021

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Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

7 January 2021

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CI-966, a GABA uptake inhibitor, antagonizes ischemia-induced neuronal degeneration in the gerbil

7 January 2021

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Transmitter amino acid release from rat neocortex: complete versus incomplete ischemia models

7 January 2021

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Amino acid and purine release in rat brain following temporary middle cerebral artery occlusion

7 January 2021

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High extracellular GABA levels in hippocampus--as a mechanism of neuronal protection in cerebral ischemia in adrenalectomized gerbils

7 January 2021

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Resolving GABAA/benzodiazepine receptors: cellular and subcellular localization in the CNS with monoclonal antibodies.

7 January 2021

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N-methylaspartate-activated calcium channels in rat brain cortex slices. Effect of calcium channel blockers and of inhibitory and depressant substances

7 January 2021

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Baclofen does not protect against cerebral ischemia in rats

7 January 2021

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Presynaptic inhibition of muscle spindle and tendon organ afferents in the mammalian spinal cord

7 January 2021

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Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist

7 January 2021

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Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]

7 January 2021

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https://api.crossref.org/works/10.1016/S0028-3908(99)00233-6

Postischemic diazepam is neuroprotective in the gerbil hippocampus

7 January 2021

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Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum.

7 January 2021

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Neuropharmacological investigations on muscimol, a psychotropic drug extracted from Amanita muscaria

7 January 2021

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Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia

7 January 2021

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Clomethiazole protects the brain in transient forebrain ischemia when used up to 4 h after the insult

7 January 2021

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Progressive decrease in extracellular GABA concentrations in the post-ischemic period in the striatum: a microdialysis study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0028-3908(99)00233-6

GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils

7 January 2021

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The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: a morphological study with early and delayed evaluations

7 January 2021

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Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

7 January 2021

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The effects of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischaemia in the rat.

7 January 2021

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Subcellular localization of benzodiazepine/GABAA receptors in the cerebellum of rat, cat, and monkey using monoclonal antibodies

7 January 2021

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Effects of felbamate on veratridine- and K( )-stimulated release of glutamate from mouse cortex

7 January 2021

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Role for gamma-aminobutyric acid in selective vulnerability in gerbils

7 January 2021

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The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat

7 January 2021

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The effect of chlormethiazole on neuronal damage in a model of transient focal ischaemia

7 January 2021

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The effect of oedema and tissue swelling on the measurement of neuroprotection; a study using chlormethiazole and permanent middle cerebral artery occlusion in rats

7 January 2021

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GABAergic neocortical neurons are resistant to NMDA receptor-mediated injury.

7 January 2021

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Is chlormethiazole neuroprotective in experimental global cerebral ischemia? A microdialysis and behavioral study

7 January 2021

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Chlormethiazole attenuates the derangement of sensory evoked potential (SEP) induced by ICV administration of NMDA

7 January 2021

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Insulin attenuates ischemic brain damage independent of its hypoglycemic effect.

7 January 2021

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Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin

7 January 2021

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Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients

7 January 2021

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Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits

7 January 2021

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GABA-activated chloride channels in secretory nerve endings

7 January 2021

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Interactions between loreclezole, chlormethiazole and pentobarbitone at GABAA receptors: functional and binding studies

7 January 2021

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Spinal cord infarction: a highly reproducible stroke model

7 January 2021

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Techniques for examining neuroprotective drugs in vivo

7 January 2021

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1016/S0028-3908(99)00233-6

1 reference

30 July 2017

1 reference