ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. (Q33938893)

30 July 2017

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title

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. (English)

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30 July 2017

R Kerb

1

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30 July 2017

S Hoffmeyer

series ordinal

2

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30 July 2017

U Brinkmann

series ordinal

3

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30 July 2017

publication date

1 February 2001

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30 July 2017

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30 July 2017

volume

2

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30 July 2017

issue

1

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30 July 2017

page(s)

51-64

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

30 July 2017

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Isolation and expression of a complementary DNA that confers multidrug resistance

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A general pattern for substrate recognition by P‐glycoprotein

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Pharmacological issues relating to viral resistance

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Expression of P-glycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response

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Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy

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Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers

21 January 2018

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Clinical trials of P-glycoprotein reversal in solid tumours

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Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase--further experimental evidence for a multisite model

21 January 2018

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Human P-Glycoprotein Exhibits Reduced Affinity for Substrates during a Catalytic Transition State

21 January 2018

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

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Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

21 January 2018

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The multidrug resistance protein family.

21 January 2018

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A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

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P-glycoprotein and multidrug resistance

21 January 2018

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Structural, mechanistic and clinical aspects of MRP1.

21 January 2018

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Molecular mechanisms of multidrug resistance in cancer chemotherapy

21 January 2018

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Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione

21 January 2018

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Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

21 January 2018

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Export pumps for glutathione S-conjugates

21 January 2018

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Export pumps for anionic conjugates encoded by MRP genes.

21 January 2018

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Hepatic secretion of conjugated drugs and endogenous substances

21 January 2018

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Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells

21 January 2018

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Do cMOAT (MRP2), other MRP homologues, and LRP play a role in MDR?

21 January 2018

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Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family.

21 January 2018

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Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

21 January 2018

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ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1.

21 January 2018

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Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.

21 January 2018

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Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein

21 January 2018

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https://api.crossref.org/works/10.1517/14622416.2.1.51

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

21 January 2018

1 reference

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ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2

21 January 2018

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https://api.crossref.org/works/10.1517/14622416.2.1.51

Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.

21 January 2018

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

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Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues

21 January 2018

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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

21 January 2018

1 reference

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Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

21 January 2018

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Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP.

21 January 2018

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Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA

21 January 2018

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An inventory of the human ABC proteins

21 January 2018

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The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells

21 January 2018

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Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome

21 January 2018

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Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome

21 January 2018

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Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

21 January 2018

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Multidrug resistance and the role of P-glycoprotein knockout mice

21 January 2018

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Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted

21 January 2018

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Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.

21 January 2018

1 reference

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

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Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1517/14622416.2.1.51

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

The pharmacological role of P-glycoprotein in the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with a report of 12 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

HIV-1 protease inhibitors and the MDR1 multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Update: genetic polymorphism of drug metabolizing enzymes in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Molecular genetics of cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

How to manage individualized drug therapy: application of pharmacogenetic knowledge of drug metabolism and transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Influence of pharmacogenetics on drug disposition and response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

Essential Dynamics from NMR Clusters: Dynamic Properties of the Myb DNA-Binding Domain and a Hinge-Bending Enhancing Variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14622416.2.1.51

21 January 2018

Identifiers

DOI

10.1517/14622416.2.1.51

1 reference

30 July 2017

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