Clinical and pharmacological experience with LJP-394. (Q33928115)

30 July 2017

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title

Clinical and pharmacological experience with LJP-394. (English)

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30 July 2017

D J Wallace

1

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30 July 2017

language of work or name

English

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publication date

1 January 2001

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Expert Opinion on Investigational Drugs

30 July 2017

published in

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30 July 2017

volume

10

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30 July 2017

issue

1

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30 July 2017

page(s)

111-117

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

30 July 2017

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Pyrophosphate stimulates wild-type and mutant cystic fibrosis transmembrane conductance regulator Cl- channels

21 January 2018

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Cystic fibrosis as a disease of misprocessing of the cystic fibrosis transmembrane conductance regulator glycoprotein

21 January 2018

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Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulator

21 January 2018

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The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Degradation of CFTR by the ubiquitin-proteasome pathway

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Chemical chaperones correct the mutant phenotype of the ΔF508 cystic fibrosis transmembrane conductance regulator protein

21 January 2018

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Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

21 January 2018

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Activation of the epithelial Na channel (ENaC) requires CFTR Cl- channel function

21 January 2018

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Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

21 January 2018

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Osmotic water permeabilities of cultured, well-differentiated normal and cystic fibrosis airway epithelia

21 January 2018

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Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid.

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro.

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Influence of molecular and chemical chaperones on protein folding

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Surface expression of the cystic fibrosis transmembrane conductance regulator mutant DeltaF508 is markedly upregulated by combination treatment with sodium butyrate and low temperature

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR

21 January 2018

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Activation of deltaF508 CFTR in a cystic fibrosis respiratory epithelial cell line by 4-phenylbutyrate, genistein and CPX.

21 January 2018

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Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells.

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Pharmacologic restoration of delta F508 CFTR-mediated chloride current.

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator delta F508 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Actions of adenosine A1 and A2 receptor antagonists on CFTR antibody-inhibited beta-adrenergic mucin secretion response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Direct activation of cystic fibrosis transmembrane conductance regulator channels by 8-cyclopentyl-1,3-dipropylxanthine (CPX) and 1,3-diallyl-8-cyclohexylxanthine (DAX).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

No evidence for direct activation of the cystic fibrosis transmembrane conductance regulator by 8-cyclopentyl-1,3-dipropylxanthine

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Use and specificity of genistein as inhibitor of protein-tyrosine kinases

21 January 2018

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Effects of isoflavone compounds on the activation of phospholipase C

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Genistein, an inhibitor of protein tyrosine kinase, is also a competitive antagonist for P1-purinergic (adenosine) receptor in FRTL-5 thyroid cells

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Interactions of flavonoids and other phytochemicals with adenosine receptors

21 January 2018

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Soy intake and cancer risk: a review of the in vitro and in vivo data

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Modulation of Cl- secretion in rat distal colon by genistein, a protein tyrosine kinase inhibitor

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Activation of cystic fibrosis transmembrane conductance regulator in rat epididymal epithelium by genistein

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Phosphatase inhibitors activate normal and defective CFTR chloride channels

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

cAMP- and Ca2 -independent activation of cystic fibrosis transmembrane conductance regulator channels by phenylimidazothiazole drugs

21 January 2018

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Regulation of CFTR by protein phosphatase 2B and protein kinase C.

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Selective activation of Ca(2 )-dependent K channels by novel benzimidazolone.

21 January 2018

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Psoriasis: current perspectives with an emphasis on treatment

21 January 2018

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Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel.

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

The actin filament disrupter cytochalasin D activates the recombinant cystic fibrosis transmembrane conductance regulator Cl- channel in mouse 3T3 fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium

21 January 2018

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https://api.crossref.org/works/10.1517/13543784.10.1.111

Characterization of immortal cystic fibrosis tracheobronchial gland epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Epithelial P2X purinergic receptor channel expression and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Regulation of intracellular calcium by extracellular nucleotides in pig tracheal submucosal gland cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Effect of luminal nucleotides on Cl- secretion and Na absorption in distal bronchi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Adenosine triphosphate: established and potential clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normal subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Effects of topically delivered benzamil and amiloride on nasal potential difference in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Pharmacologic modulation of salt and water in the airway epithelium in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Nebulised amiloride in respiratory exacerbations of cystic fibrosis: a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

The effect of topical benzamil and amiloride on nasal potential difference in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Anion selectivity of apical membrane conductance of Calu 3 human airway epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

Retrograde protein translocation: ERADication of secretory proteins in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.10.1.111

10.1517/13543784.10.1.111

21 January 2018

Identifiers

DOI

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30 July 2017

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