Alzheimer disease beta-amyloid activity mimics cholesterol oxidase (Q33925332)

30 July 2017

title

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase (English)

1 reference

30 July 2017

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John D Wade

8

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Ashley I. Bush

object named as

Ashley I Bush

11

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Carlos Opazo

object named as

Carlos Opazo

5

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author name string

Luigi Puglielli

1

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30 July 2017

Avi L Friedlich

2

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30 July 2017

Kenneth D R Setchell

3

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30 July 2017

Seiichi Nagano

4

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30 July 2017

Robert A Cherny

6

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30 July 2017

Kevin J Barnham

7

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30 July 2017

Simon Melov

9

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30 July 2017

Dora M Kovacs

10

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30 July 2017

language of work or name

English

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publication date

25 August 2005

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Journal of Clinical Investigation

30 July 2017

published in

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30 July 2017

volume

115

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30 July 2017

issue

9

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30 July 2017

page(s)

2556-2563

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Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.

30 July 2017

cites work

1 reference

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5 July 2018

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5 July 2018

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

5 July 2018

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Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease.

5 July 2018

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

5 July 2018

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In vivo reduction of amyloid-beta by a mutant copper transporter

5 July 2018

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Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

5 July 2018

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Sub-atomic resolution crystal structure of cholesterol oxidase: what atomic resolution crystallography reveals about enzyme mechanism and the role of the FAD cofactor in redox activity

5 July 2018

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

5 July 2018

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Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

5 July 2018

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Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis

5 July 2018

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Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

5 July 2018

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Identification and mutagenesis by allelic exchange of choE, encoding a cholesterol oxidase from the intracellular pathogen Rhodococcus equi

5 July 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

5 July 2018

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

5 July 2018

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5 July 2018

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Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice

5 July 2018

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Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

5 July 2018

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Cholesterol oxidase: sources, physical properties and analytical applications

5 July 2018

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Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes

5 July 2018

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

5 July 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques

5 July 2018

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Investigation of membrane disruption in the reaction catalyzed by cholesterol oxidase

5 July 2018

1 reference

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A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide

5 July 2018

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Biosynthesis of cholestanol: conversion of cholesterol into 4-cholesten-3-one by rat liver microsomes.

5 July 2018

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Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis

5 July 2018

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Effects of cholesterol oxidase on cultured vascular smooth muscle cells

5 July 2018

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

5 July 2018

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Mass spectra of Δ4- and 5α-3-ketosteroids formed during the oxidation of some 3β-hydroxysteroids by cholesterol oxidase

5 July 2018

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Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

5 July 2018

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The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

29 October 2018

1 reference

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The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

29 October 2018

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Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

29 October 2018

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Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

29 October 2018

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Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity.

29 October 2018

1 reference

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Cholesterol and neuropathologic markers of AD: a population-based autopsy study

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Oxidative damage is the earliest event in Alzheimer disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Transformation of 4-cholesten-3-one and 7 alpha-hydroxy-4-cholesten-3-one into cholestanol and bile acids in cerebrotendinous xanthomatosis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Cerebrotendinous xanthomatosis. The storage of cholestanol within the nervous system

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190368

Mass spectrometry in structural and stereochemical problems. 78. Steroidal delta-4-3,6-diketones

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The multicomponent analysis of conjugates of neutral steroids in urine by lipophilic ion exchange chromatography and computerised gas chromatography-mass spectrometry

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Intracellular transport of cholesterol to the plasma membrane

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Copper salt-dependent hydroxyl radical formation. Damage to proteins acting as antioxidants

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Oxidation of cholesterol moiety of low density lipoprotein in the presence of human endothelial cells or Cu 2 ions: identification of major products and their effects

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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Identifiers

DOI

10.1172/JCI23610

1 reference

30 July 2017

1 reference

30 July 2017

1 reference