Transformation of human and murine fibroblasts without viral oncoproteins (Q33925306)

30 July 2017

title

Transformation of human and murine fibroblasts without viral oncoproteins (English)

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30 July 2017

4

William C Hahn

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30 July 2017

1

Jesse S Boehm

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30 July 2017

Meghan T Hession

2

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30 July 2017

Sara E Bulmer

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

1 August 2005

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Molecular and Cellular Biology

30 July 2017

published in

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30 July 2017

volume

25

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30 July 2017

issue

15

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30 July 2017

page(s)

6464-6474

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Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells

30 July 2017

cites work

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Normal human fibroblasts are resistant to RAS-induced senescence

5 July 2018

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Identification of specific PP2A complexes involved in human cell transformation

5 July 2018

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Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

5 July 2018

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The serial cultivation of human diploid cell strains

5 July 2018

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

5 July 2018

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Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

5 July 2018

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Distinct requirements for Ras oncogenesis in human versus mouse cells

5 July 2018

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INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

5 July 2018

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

5 July 2018

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Critical role for SV40 small-t antigen in human cell transformation

5 July 2018

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Cellular senescence as a tumor-suppressor mechanism

5 July 2018

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The role of the SV40 ST antigen in cell growth promotion and transformation

5 July 2018

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

5 July 2018

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Identification of CDK4 as a target of c-MYC.

5 July 2018

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Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

5 July 2018

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Creation of human tumour cells with defined genetic elements

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Direct activation of TERT transcription by c-MYC.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

5 July 2018

1 reference

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5 July 2018

Myc activates telomerase

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Extension of life-span by introduction of telomerase into normal human cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Developmental and tissue-specific regulation of mouse telomerase and telomere length

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Telomerase activity in normal and malignant hematopoietic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Ploidy of human embryonic fibroblasts during in vitro aging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Activated v-myc and v-ras oncogenes do not transform normal human lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Suppression of tumor growth by senescence in virally transformed human fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

The p53 proto-oncogene can act as a suppressor of transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Hypervariable ultra-long telomeres in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Telomere length predicts replicative capacity of human fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Efficient retroviral-mediated gene transfer into human B lymphoblastoid cells expressing mouse ecotropic viral receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Immortalization of primary human prostate epithelial cells by c-Myc.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Telomerase maintains telomere structure in normal human cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Transformation of normal human cells in the absence of telomerase activation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1190359

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

29 October 2018

1 reference

12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

12 December 2020

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

1 reference

12 December 2020

The tumor-suppressive functions of the human INK4A locus

1 reference

12 December 2020

Species- and cell type-specific requirements for cellular transformation

1 reference

12 December 2020

10.1128/MCB.25.15.6464-6474.2005

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference