Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression. (Q33914314)

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English	Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression.	scientific article

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2 February 2020

Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression (English)

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2 February 2020

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Carlos M Telleria

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Chelsea R Tieszen

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2 February 2020

Alicia A Goyeneche

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BreeAnn N Brandhagen

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2 February 2020

Casey T Ortbahn

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27 May 2011

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2 February 2020

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2 February 2020

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2 February 2020

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Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

MCF-7 cell apoptosis and cell cycle arrest: non-genomic effects of progesterone and mifepristone (RU-486)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Atypical induction of the unfolded protein response by mifepristone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications

1 reference

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5 July 2018

Glucocorticoid receptor-beta and receptor-gamma exert dominant negative effect on gene repression but not on gene induction

1 reference

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5 July 2018

Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice

1 reference

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5 July 2018

High concentrations of progesterone and mifepristone mutually reinforce cell cycle retardation and induction of apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Levonorgestrel, medroxyprogesterone and progesterone cause a concentration-dependent reduction in endometrial cancer (Ishikawa) cell density, and high concentrations of progesterone and mifepristone act in synergy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Mifepristone abrogates repopulation of ovarian cancer cells in between courses of cisplatin treatment

1 reference

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5 July 2018

PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding

1 reference

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5 July 2018

Non-genomic progesterone actions in female reproduction.

1 reference

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5 July 2018

Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

The antisteroid RU486: its cellular and molecular mode of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Regulation of ovarian cancer cell viability and sensitivity to cisplatin by progesterone receptor membrane component-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Mifepristone inhibits ovarian cancer cell growth in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Human glucocorticoid receptor beta binds RU-486 and is transcriptionally active.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins.

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5 July 2018

Effects of progesterone and anti-progestin (mifepristone) treatment on proliferation and apoptosis of the human ovarian cancer cell line, OVCAR-3.

1 reference

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5 July 2018

Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Meningioma and hormonal influences

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5 July 2018

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Molecular origins for the dominant negative function of human glucocorticoid receptor beta

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5 July 2018

Repressors of androgen and progesterone receptor action

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

Expression of progesterone receptor isoforms A and B is differentially regulated by estrogen in different breast cancer cell lines.

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5 July 2018

Methylation and inactivation of estrogen, progesterone, and androgen receptors in prostate cancer

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5 July 2018

Demonstration of mixed properties of RU486 in progesterone receptor (PR)-transfected MDA-MB-231 cells: a model for studying the functions of progesterone analogues

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5 July 2018

High-dose progesterone inhibition of urokinase secretion and invasive activity by SKOV-3 ovarian carcinoma cells: evidence for a receptor-independent nongenomic effect on the plasma membrane

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5 July 2018

RU486-induced growth inhibition of human endometrial cells

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5 July 2018

Growth factor-dependent induction of p21(CIP1) by the green tea polyphenol, epigallocatechin gallate

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5 July 2018

Antitumor activity of mifepristone in the human LNCaP, LNCaP-C4, and LNCaP-C4-2 prostate cancer models in nude mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125282

5 July 2018

The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action

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5 July 2018

Induction of cyclin-dependent kinase inhibitors and G(1) prolongation by the chemopreventive agent N-acetylcysteine

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5 July 2018

Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids

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5 July 2018

Growth inhibition of human in vitro and mouse in vitro and in vivo mammary tumor models by retinoids in comparison with tamoxifen and the RU-486 anti-progestagen.

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5 July 2018

Mifepristone (RU486): A review

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Inhibition of growth of the human malignant glioma cell line (U87MG) by the steroid hormone antagonist RU486.

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5 July 2018

Antioxidant: a new role for RU-486 and related compounds

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5 July 2018

LNCaP model of human prostatic carcinoma.

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5 July 2018

The antiprogestin RU38 486: receptor-mediated progestin versus antiprogestin actions screened in estrogen-insensitive T47Dco human breast cancer cells.

1 reference

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5 July 2018

Characterization of a newly established malignant meningioma cell line of the human brain: IOMM-Lee

1 reference

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5 July 2018

Combined effects of RU486 and tamoxifen on the growth and cell cycle phases of the MCF-7 cell line

1 reference

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5 July 2018

Growth inhibition of androgen-insensitive human prostate carcinoma cells by a 19-norsteroid derivative agent, mifepristone

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21 January 2018

Inhibitory effects of 17beta-estradiol and progesterone on ovarian carcinoma cell proliferation: a potential role for inducible nitric oxide synthase

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21 January 2018

Long-term administration of mifepristone (RU486): clinical tolerance during extended treatment of meningioma

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21 January 2018

Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells

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21 January 2018

Nuclear estrogen receptor release from antiestrogen suppression: amplified induction of progesterone receptor in MCF-7 human breast cancer cells

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21 January 2018

Progesterone receptor expression in human prostate cancer: correlation with tumor progression

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21 January 2018

Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1.

1 reference

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29 October 2018

Additive effect of mifepristone and tamoxifen on apoptotic pathways in MCF-7 human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of RU-486 and related compounds on the proliferation of cultured macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of endometrial cancer cell lines by mifepristone (RU 486)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective progesterone receptor modulators 3: use in oncology, endocrinology and psychiatry

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective progesterone receptor modulators 1: use during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen receptor in a human cell line (MCF-7) from breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of patients receiving long-term treatment with mifepristone

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of human ovarian carcinoma cell lines to antiprogestin mifepristone

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by mifepristone and tamoxifen in human LNCaP prostate cancer cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigational developments for the treatment of progesterone-dependent diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of progesterone receptor with 17 beta-estradiol in human ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective progesterone receptor modulators 2: use in reproductive medicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21619605

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-2407-11-207

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21619605 AND SRC:MED&resulttype=core&format=json

2 February 2020

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21619605 AND SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21619605 AND SRC:MED&resulttype=core&format=json

2 February 2020

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