Intensive insulin therapy protects the endothelium of critically ill patients (Q33905796)

29 July 2017

title

Intensive insulin therapy protects the endothelium of critically ill patients (English)

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29 July 2017

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8

Greet Van den Berghe

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Ilse Vanhorebeek

2

Ilse Vanhorebeek

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Kristin Skogstrand

Kristin Skogstrand

6

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Lies Langouche

Lies Langouche

1

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Sarah Vander Perre

4

Sarah Vander Perre

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29 July 2017

5

Pieter J Wouters

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29 July 2017

3

Dirk Vlasselaers

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29 July 2017

Troels K Hansen

7

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29 July 2017

language of work or name

English

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publication date

1 August 2005

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Journal of Clinical Investigation

29 July 2017

published in

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29 July 2017

volume

115

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29 July 2017

issue

8

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29 July 2017

page(s)

2277-2286

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How does blood glucose control with insulin save lives in intensive care?

29 July 2017

cites work

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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A novel in vivo rabbit model of hypercatabolic critical illness reveals a biphasic neuroendocrine stress response

28 July 2018

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Intensive insulin therapy in critically ill patients

28 July 2018

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28 July 2018

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28 July 2018

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Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 are increased in the plasma of children with sepsis-induced multiple organ failure

28 July 2018

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28 July 2018

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Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

28 July 2018

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Increased mortality associated with growth hormone treatment in critically ill adults

28 July 2018

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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

28 July 2018

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28 July 2018

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28 July 2018

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Soluble E-selectin levels in sepsis and critical illness. Correlation with infection and hemodynamic dysfunction

28 July 2018

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Oxidative stress and diabetic vascular complications

28 July 2018

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The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase

28 July 2018

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Pathogenetic mechanisms of septic shock

28 July 2018

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The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors

28 July 2018

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APACHE II: a severity of disease classification system

28 July 2018

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Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing

28 July 2018

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Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

28 July 2018

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Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion

28 July 2018

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Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients

28 July 2018

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Serum interleukin-10 in ICU patients with severe acute central nervous system injuries

29 October 2018

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Vascular endothelial growth factor serum level is strongly enhanced after burn injury and correlated with local and general tissue edema

29 October 2018

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The relationship between glycemic control and plasma vascular endothelial growth factor and endothelin-1 concentration in diabetic patients

29 October 2018

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Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect

29 October 2018

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Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-kappaB in mononuclear cells

29 October 2018

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Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Association of proinflammatory molecules with apoptotic markers and survival in critically ill multiple organ dysfunction patients.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness

29 October 2018

1 reference

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Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury

29 October 2018

1 reference

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The biology of VEGF and its receptors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Physiological mechanisms regulating the expression of endothelial-type NO synthase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Association between mitochondrial dysfunction and severity and outcome of septic shock

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Sustained endotoxemia leads to marked down-regulation of early steps in the insulin-signaling cascade.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Angiogenesis in wound healing

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Radicals and oxidative stress in diabetes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Analysis of neuronal nitric oxide synthase isoform expression and identification of human nNOS-mu

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Circulating ICAM-1 is increased in septic shock

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome: a prospective cohort study.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Intensive Insulin Therapy Exerts Antiinflammatory Effects in Critically Ill Patients and Counteracts the Adverse Effect of Low Mannose-Binding Lectin Levels

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180545

Circulating IL-1ra and IL-10 levels are increased but do not predict the development of acute respiratory distress syndrome in at-risk patients

29 October 2018

1 reference

12 December 2020

Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn

1 reference

12 December 2020

Do plasma levels of circulating soluble adhesion molecules differ between surviving and nonsurviving critically ill patients?

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12 December 2020

Simplified Therapeutic Intervention Scoring System: the TISS-28 items--results from a multicenter study

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12 December 2020

Effect of insulin on human aortic endothelial nitric oxide synthase

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12 December 2020

Inhibition of CD11-CD18 complex prevents acute lung injury and reduces mortality after peritonitis in rabbits

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12 December 2020

Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with Type 1 diabetes mellitus: relation to glycaemic control and microvascular complications

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12 December 2020

Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome

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12 December 2020

Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells

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12 December 2020

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein

1 reference

12 December 2020

Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock

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12 December 2020

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1 reference

12 December 2020

Relation between pro- and anti-inflammatory cytokines and the production of nitric oxide (NO) in severe sepsis

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12 December 2020

Identifiers

DOI

10.1172/JCI25385

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29 July 2017

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29 July 2017

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