Human liver expression of CYP2C8: gender, age, and genotype effects (Q33891033)

29 July 2017

title

Human liver expression of CYP2C8: gender, age, and genotype effects (English)

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29 July 2017

5

Bruce M Psaty

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29 July 2017

author name string

Suresh Babu Naraharisetti

1

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29 July 2017

Yvonne S Lin

2

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29 July 2017

Mark J Rieder

3

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29 July 2017

Kristin D Marciante

4

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29 July 2017

Kenneth E Thummel

6

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29 July 2017

Rheem A Totah

7

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29 July 2017

publication date

26 February 2010

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Drug Metabolism and Disposition

29 July 2017

published in

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29 July 2017

volume

38

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29 July 2017

issue

6

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29 July 2017

page(s)

889-893

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Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies

29 July 2017

cites work

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Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha

5 July 2018

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Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance

5 July 2018

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Protein measurement with the Folin phenol reagent

5 July 2018

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Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide

5 July 2018

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Sex is a major determinant of CYP3A4 expression in human liver

5 July 2018

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CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide

5 July 2018

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Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

5 July 2018

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The xenobiotic inhibitor profile of cytochrome P4502C8.

5 July 2018

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5 July 2018

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Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation

5 July 2018

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Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism.

5 July 2018

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Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

5 July 2018

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Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism

5 July 2018

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5 July 2018

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Metabolism of cerivastatin by human liver microsomes in vitro. Characterization of primary metabolic pathways and of cytochrome P450 isozymes involved

5 July 2018

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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

5 July 2018

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Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-( )- and (R)-(-)-ibuprofen hydroxylation in vitro

5 July 2018

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Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism

29 October 2018

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Trimethoprim and the CYP2C8*3 allele have opposite effects on the pharmacokinetics of pioglitazone

29 October 2018

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Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa

29 October 2018

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Novel metabolites of buprenorphine detected in human liver microsomes and human urine

29 October 2018

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Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

29 October 2018

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Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms

29 October 2018

1 reference

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Sex is a major determinant of CYP3A4 expression in human liver

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879956

Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes

29 October 2018

1 reference

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Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879956

Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation

29 October 2018

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12 December 2020

Variability in human cytochrome P450 paclitaxel metabolism

1 reference

12 December 2020

Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of rosiglitazone in relation to CYP2C8 genotype

1 reference

12 December 2020

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

1 reference

12 December 2020

Identifiers

DOI

10.1124/DMD.109.031542

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29 July 2017

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29 July 2017

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