Regulation of basal cellular physiology by the homeostatic unfolded protein response (Q33886820)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

review article

1 reference

title

Regulation of basal cellular physiology by the homeostatic unfolded protein response (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

main subject

physiological phenomenon

1 reference

PubMed

regulation of gene expression

20 August 2019

1 reference

8 September 2019

1 reference

12 October 2019

0 references

Ramanujan Shankar Hegde

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

Thomas Rutkowski

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

author name string

D Thomas Rutkowski

series ordinal

1

1 reference

PubMed publication ID

20513765

29 July 2017

language of work or name

English

0 references

publication date

1 May 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

number of pages

12

1 reference

based on heuristic

inferred from page(s)

published in

Journal of Cell Biology

4 references

20 August 2019

8 September 2019

12 October 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

volume

189

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

page(s)

783-794

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

4 February 2020

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5 July 2018

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A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response

5 July 2018

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Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver

5 July 2018

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5 July 2018

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Regulated increase in folding capacity prevents unfolded protein stress in the ER.

5 July 2018

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5 July 2018

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5 July 2018

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Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response

5 July 2018

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Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling

5 July 2018

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Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

5 July 2018

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Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

5 July 2018

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Regulation of tissue growth through nutrient sensing

5 July 2018

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Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

5 July 2018

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IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

5 July 2018

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Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

5 July 2018

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Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance

5 July 2018

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The endoplasmic reticulum stress response and aging

5 July 2018

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Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance

5 July 2018

1 reference

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Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis.

5 July 2018

1 reference

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Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

5 July 2018

1 reference

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XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

5 July 2018

1 reference

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GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

5 July 2018

1 reference

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Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis

5 July 2018

1 reference

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BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

5 July 2018

1 reference

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Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum

5 July 2018

1 reference

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pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation.

5 July 2018

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UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

5 July 2018

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Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions

5 July 2018

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Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

5 July 2018

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From endoplasmic-reticulum stress to the inflammatory response

5 July 2018

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ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

5 July 2018

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Regulation of hepatic lipogenesis by the transcription factor XBP1

5 July 2018

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Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

5 July 2018

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IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.

5 July 2018

1 reference

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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

5 July 2018

1 reference

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IRE1 signaling affects cell fate during the unfolded protein response

5 July 2018

1 reference

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Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response

5 July 2018

1 reference

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The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

5 July 2018

1 reference

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PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress

5 July 2018

1 reference

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XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

5 July 2018

1 reference

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Diseases originating from altered protein quality control in the endoplasmic reticulum.

5 July 2018

1 reference

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Signal integration in the endoplasmic reticulum unfolded protein response

5 July 2018

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A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response

5 July 2018

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GRP78 induction in cancer: therapeutic and prognostic implications.

5 July 2018

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The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

5 July 2018

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Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway

5 July 2018

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The MEK/ERK cascade: from signaling specificity to diverse functions

5 July 2018

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Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins

5 July 2018

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The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

5 July 2018

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

5 July 2018

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Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

5 July 2018

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Endoplasmic reticulum stress in health and disease

5 July 2018

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Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

5 July 2018

1 reference

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Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

5 July 2018

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pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response

5 July 2018

1 reference

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On the mechanism of sensing unfolded protein in the endoplasmic reticulum

5 July 2018

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Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response

5 July 2018

1 reference

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Coping with stress: eIF2 kinases and translational control

5 July 2018

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CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

5 July 2018

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Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP

5 July 2018

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Endoplasmic reticulum stress response and neurodegeneration

5 July 2018

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Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

5 July 2018

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Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

5 July 2018

1 reference

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Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR

5 July 2018

1 reference

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

5 July 2018

1 reference

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Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6.

5 July 2018

1 reference

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ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome

5 July 2018

1 reference

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PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

5 July 2018

1 reference

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Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

5 July 2018

1 reference

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Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.

5 July 2018

1 reference

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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

5 July 2018

1 reference

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Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

5 July 2018

1 reference

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Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2

5 July 2018

1 reference

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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

5 July 2018

1 reference

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Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

A central role for JNK in obesity and insulin resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Activation of an unfolded protein response during differentiation of antibody-secreting B cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

B cell development pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

5 July 2018

1 reference

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Perk is essential for translational regulation and cell survival during the unfolded protein response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Retroviral insertional mutagenesis as a strategy to identify cancer genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

B- and T-cell development both involve activity of the unfolded protein response pathway

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

A transgenic mouse model for monitoring endoplasmic reticulum stress

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

Bypassing a Kinase Activity with an ATP-Competitive Drug

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

The unfolded protein response: an intracellular signalling pathway with many surprising features

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878945

29 October 2018

Identifiers

DOI

10.1083/JCB.201003138

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20513765 AND SRC:MED&resulttype=core&format=json

4 February 2020

PubMed publication ID

20513765

1 reference