Lnk constrains myeloproliferative diseases in mice (Q33882944)

29 July 2017

title

Lnk constrains myeloproliferative diseases in mice (English)

1 reference

29 July 2017

5

Mondira Kundu

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author name string

Alexey Bersenev

1

1 reference

29 July 2017

Chao Wu

2

1 reference

29 July 2017

Joanna Balcerek

3

1 reference

29 July 2017

Jiang Jing

4

1 reference

29 July 2017

Gerd A Blobel

6

1 reference

29 July 2017

Kudakwashe R Chikwava

7

1 reference

29 July 2017

Wei Tong

8

1 reference

29 July 2017

language of work or name

English

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publication date

10 May 2010

1 reference

Journal of Clinical Investigation

29 July 2017

published in

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29 July 2017

volume

120

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29 July 2017

issue

6

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29 July 2017

page(s)

2058-2069

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Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome

29 July 2017

cites work

1 reference

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5 July 2018

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Expression of the adaptor protein Lnk in leukemia cells

5 July 2018

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Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

5 July 2018

1 reference

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Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2

5 July 2018

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The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells

5 July 2018

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MLL translocations, histone modifications and leukaemia stem-cell development

5 July 2018

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5 July 2018

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Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders

5 July 2018

1 reference

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Oncogenes in myeloproliferative disorders

5 July 2018

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Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

5 July 2018

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Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.

5 July 2018

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Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.

5 July 2018

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JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

5 July 2018

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5 July 2018

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Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

5 July 2018

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Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells

5 July 2018

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Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow

5 July 2018

1 reference

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

5 July 2018

1 reference

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

5 July 2018

1 reference

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

5 July 2018

1 reference

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Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways

5 July 2018

1 reference

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Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis

5 July 2018

1 reference

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Some speculations on the myeloproliferative syndromes.

5 July 2018

1 reference

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Negative regulation of cytokine signaling and inflammatory diseases

5 July 2018

1 reference

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SH2 and PTB domains in tyrosine kinase signaling

5 July 2018

1 reference

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

5 July 2018

1 reference

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Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice

5 July 2018

1 reference

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Lnk adaptor: novel negative regulator of B cell lymphopoiesis

5 July 2018

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Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins

5 July 2018

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5 July 2018

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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

5 July 2018

1 reference

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Structure and function of the cytokine receptor superfamily

5 July 2018

1 reference

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

5 July 2018

1 reference

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Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877957

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877957

Cytokine receptor signal transduction and the control of hematopoietic cell development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877957

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877957

Molecular and functional analysis of the stem cell compartment of chronic myelogenous leukemia reveals the presence of a CD34- cell population with intrinsic resistance to imatinib

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877957

Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877957

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877957

Gene expression analysis of purified hematopoietic stem cells and committed progenitors

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20458146

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20458146

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI42032

1 reference

29 July 2017

1 reference

29 July 2017

1 reference