Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia. (Q33882849)

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2 February 2020

title

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia (English)

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2 February 2020

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1

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2 February 2020

author name string

Hui Luo

2

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2 February 2020

Jacqueline E Payton

3

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2 February 2020

Jennifer Cain

4

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2 February 2020

Timothy J Ley

5

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2 February 2020

Joseph T Opferman

6

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2 February 2020

Michael H Tomasson

7

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2 February 2020

language of work or name

English

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publication date

17 May 2010

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Journal of Clinical Investigation

2 February 2020

published in

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volume

120

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2 February 2020

issue

6

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2 February 2020

page(s)

2109-2118

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FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation

2 February 2020

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MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family

5 July 2018

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Distinct thresholds govern Myc's biological output in vivo

5 July 2018

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Reflecting on 25 years with MYC.

5 July 2018

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mTORC1 promotes survival through translational control of Mcl-1.

5 July 2018

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5 July 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Transcriptional regulation and transformation by Myc proteins

5 July 2018

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c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations.

5 July 2018

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Drug therapy for acute myeloid leukemia

5 July 2018

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MCL-1 expression in B-cell non-Hodgkin's lymphomas

5 July 2018

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Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.

5 July 2018

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c-MYC: more than just a matter of life and death

5 July 2018

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

5 July 2018

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Myeloid cell factor-1 is a critical survival factor for multiple myeloma

5 July 2018

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5 July 2018

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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

5 July 2018

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Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

5 July 2018

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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

5 July 2018

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5 July 2018

The Hallmarks of Cancer

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The proto-oncogene c-myc blocks myeloid differentiation independently of its target gene ornithine decarboxylase.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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29 October 2018

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MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

29 October 2018

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29 October 2018

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29 October 2018

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29 October 2018

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Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.

29 October 2018

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More than just proliferation: Myc function in stem cells

29 October 2018

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Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression

29 October 2018

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12 December 2020

Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions

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12 December 2020

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

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12 December 2020

Bcl-2 proteins and apoptosis: choose your partner

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12 December 2020

Overexpression of N-Myc rapidly causes acute myeloid leukemia in mice

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12 December 2020

Identifiers

DOI

10.1172/JCI39964

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20484815 AND SRC:MED&resulttype=core&format=json

2 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20484815 AND SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

20484815

1 reference