Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102. (Q33880729)

29 July 2017

title

Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102. (English)

1 reference

29 July 2017

4

Michael Andreeff

1 reference

29 July 2017

John M Fidler

1

1 reference

29 July 2017

Jinhua An

series ordinal

2

1 reference

29 July 2017

Bing Z Carter

series ordinal

3

1 reference

29 July 2017

publication date

12 March 2014

1 reference

Cancer Chemotherapy and Pharmacology

29 July 2017

published in

1 reference

29 July 2017

volume

73

1 reference

29 July 2017

issue

5

1 reference

29 July 2017

page(s)

961-974

1 reference

A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Inhibiting eukaryotic transcription. Which compound to choose? How to evaluate its activity?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

XPB, a subunit of TFIIH, is a target of the natural product triptolide.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34 primitive progenitor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

A novel hematopoietic multilineage clone, Myl-D-7, is stromal cell-dependent and supported by an alternative mechanism(s) independent of stem cell factor/c-kit interaction.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Comparative clinical study of rheumatoid arthritis treated by triptolide and an ethyl acetate extract of Tripterygium wilfordii

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007/S00280-014-2428-6

Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007/S00280-014-2428-6

Solid lipid nanoparticle and microemulsion for topical delivery of triptolide

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007/S00280-014-2428-6

Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091685

Human acute myeloid leukemia CD34 /CD38- progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities

29 October 2018

1 reference

12 December 2020

In vitro and in vivo evaluation of Triptolide-loaded pluronic P105 polymeric micelles

1 reference

12 December 2020

Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours

1 reference

12 December 2020

Tumor inhibitors. LXXIV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii

1 reference

12 December 2020

Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in rats.

1 reference

12 December 2020

10.1007/S00280-014-2428-6

Identifiers

DOI

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference