Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis (Q33859205)

29 July 2017

title

Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis (English)

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29 July 2017

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Meghan Morrison Joly

1

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29 July 2017

Michelle M Williams

2

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29 July 2017

Donna J Hicks

3

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29 July 2017

Bayley Jones

4

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29 July 2017

Violeta Sanchez

5

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29 July 2017

Christian D Young

6

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29 July 2017

Dos D Sarbassov

7

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29 July 2017

William J Muller

8

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29 July 2017

Dana Brantley-Sieders

9

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29 July 2017

Rebecca S Cook

10

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29 July 2017

publication date

30 June 2017

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29 July 2017

published in

Breast Cancer Research

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29 July 2017

volume

19

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29 July 2017

issue

1

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29 July 2017

page(s)

74

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Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers.

29 July 2017

cites work

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PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2.

5 July 2018

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mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis

5 July 2018

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Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

ErbB3 downregulation enhances luminal breast tumor response to antiestrogens

5 July 2018

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Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Conditional astroglial Rictor overexpression induces malignant glioma in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Rictor regulates cell migration by suppressing RhoGDI2.

5 July 2018

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Targeting of Rac GTPases blocks the spread of intact human breast cancer.

5 July 2018

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Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer.

5 July 2018

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Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT).

5 July 2018

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The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium

5 July 2018

1 reference

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mTOR complex 2 signaling and functions

5 July 2018

1 reference

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Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

mTOR Complex Component Rictor Interacts with PKCζ and Regulates Cancer Cell Metastasis

5 July 2018

1 reference

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HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

mTOR signaling at a glance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Metastasis: from dissemination to organ-specific colonization

5 July 2018

1 reference

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The ShcA adaptor protein is a critical regulator of breast cancer progression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Akt/PKB regulates actin organization and cell motility via Girdin/APE

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5493112

mTORC2 regulates PGE2-mediated endothelial cell survival and migration

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186/S13058-017-0868-8

Gene targeting of ErbB3 using a Cre-mediated unidirectional DNA inversion strategy

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186/S13058-017-0868-8

EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186/S13058-017-0868-8

10.1186/S13058-017-0868-8

21 January 2018

Identifiers

DOI

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Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference