Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. (Q33857802)

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title

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation (English)

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7

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8

A J Morton

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author name string

R J Carter

1

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L A Lione

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T Humby

3

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L Mangiarini

4

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A Mahal

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G P Bates

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language of work or name

English

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publication date

1 April 1999

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3 December 2019

published in

Journal of Neuroscience

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volume

19

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issue

8

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page(s)

3248-3257

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Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's disease

3 December 2019

cites work

1 reference

12 December 2020

Huntington's disease: translating a CAG repeat into a pathogenic mechanism

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12 December 2020

Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid

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12 December 2020

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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12 December 2020

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

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12 December 2020

The quinolinic acid model of Huntington's disease: locomotor abnormalities

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12 December 2020

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

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12 December 2020

Striatal transplantation in a transgenic mouse model of Huntington's disease

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12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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12 December 2020

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

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12 December 2020

Mitochondrial toxin 3-nitropropionic acid produces startle reflex abnormalities and striatal damage in rats that model some features of Huntington's disease

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12 December 2020

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

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12 December 2020

Trinucleotide repeats in neurogenetic disorders

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12 December 2020

Mouse Models of Human CAG Repeat Disorders

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12 December 2020

Prepulse inhibition in the rat is regulated by ventral and caudodorsal striato-pallidal circuitry

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12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease

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12 December 2020

The gait abnormality of Huntington's disease

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12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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12 December 2020

10.1523/JNEUROSCI.19-08-03248.1999

Identifiers

DOI

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PubMed publication ID

10191337

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