Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. (Q33839850)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20185581 AND SRC:MED&resulttype=core&format=json

18 January 2020

title

Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma (English)

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18 January 2020

5

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18 January 2020

Eileen White

10

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18 January 2020

author name string

Gaofeng Fan

1

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18 January 2020

Matthew J Simmons

2

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18 January 2020

Sheng Ge

3

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18 January 2020

Jui Dutta-Simmons

4

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18 January 2020

Yacov Ron

6

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18 January 2020

David Weissmann

7

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18 January 2020

Chiann-Chyi Chen

8

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18 January 2020

Chandreyee Mukherjee

9

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18 January 2020

Céline Gélinas

11

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18 January 2020

language of work or name

English

0 references

publication date

25 February 2010

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18 January 2020

number of pages

11

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inferred from page(s)

published in

Blood

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18 January 2020

volume

115

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18 January 2020

issue

17

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18 January 2020

page(s)

3559-3569

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The BCL-2 protein family: opposing activities that mediate cell death

18 January 2020

cites work

1 reference

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

5 July 2018

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Upregulation of bfl-1 is a potential mechanism of chemoresistance in B-cell chronic lymphocytic leukaemia

5 July 2018

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Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist

5 July 2018

1 reference

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The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis

5 July 2018

1 reference

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Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

5 July 2018

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Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis

5 July 2018

1 reference

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

5 July 2018

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Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes.

5 July 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

5 July 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

5 July 2018

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Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis

5 July 2018

1 reference

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

5 July 2018

1 reference

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A novel link between Lck, Bak expression and chemosensitivity.

5 July 2018

1 reference

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The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression

5 July 2018

1 reference

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Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor.

5 July 2018

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

5 July 2018

1 reference

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NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes

5 July 2018

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The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

5 July 2018

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High expression of bfl-1 contributes to the apoptosis resistant phenotype in B-cell chronic lymphocytic leukemia.

5 July 2018

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Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck.

5 July 2018

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

5 July 2018

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NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1

5 July 2018

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5 July 2018

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Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

5 July 2018

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

5 July 2018

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MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

5 July 2018

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

5 July 2018

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A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation.

5 July 2018

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

5 July 2018

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Thymic tumorigenesis induced by overexpression of p56lck

5 July 2018

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Profound block in thymocyte development in mice lacking p56lck

5 July 2018

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

5 July 2018

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Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

5 July 2018

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The stability and anti-apoptotic function of A1 are controlled by its C terminus

29 October 2018

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Bfl-1S, a novel alternative splice variant of Bfl-1, localizes in the nucleus via its C-terminus and prevents cell death

29 October 2018

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Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo.

29 October 2018

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In vivo suppression of Bcl-XL expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model

29 October 2018

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Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

29 October 2018

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Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.

29 October 2018

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A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20185581

12 December 2020

inferred from PubMed ID database lookup

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20185581

12 December 2020

inferred from PubMed ID database lookup

Expression of the T-cell-specific tyrosine kinase Lck in normal B-1 cells and in chronic lymphocytic leukemia B cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20185581

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1182/BLOOD-2009-08-236760

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20185581 AND SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20185581 AND SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

20185581

1 reference