The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) /CD4 T cells as key targets in mucosal transmission (Q33839456)

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English	The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) /CD4 T cells as key targets in mucosal transmission	scientific article

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29 July 2017

The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) /CD4 T cells as key targets in mucosal transmission (English)

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29 July 2017

HIV transmission

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Anthony S Fauci

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Claudia Cicala

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James Arthos

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Katija Jelicic

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Massimiliano Pascuccio

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Massimiliano Pascuccio

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Danlan Wei

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Jonathan P McNally

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Jonathan P McNally

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29 July 2017

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Fatima Nawaz

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Donald Van Ryk

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Katharine E Block

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29 July 2017

Olajumoke Ogundare

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Nikita Patel

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29 July 2017

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24 February 2011

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29 July 2017

2

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29 July 2017

e1001301

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29 July 2017

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Creative Commons CC0 License

24 February 2011

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copyrighted, dedicated to the public domain by copyright holder

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Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens.

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Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design

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Targeting early infection to prevent HIV-1 mucosal transmission.

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Specificity of the autologous neutralizing antibody response

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Genetic and antigenic features of the transmitted virus

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The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

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Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infection

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Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways

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Two different homing pathways involving integrin β7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following Chlamydia muridarum infection

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The combination of the gastrointestinal integrin (α4β7) and selectin ligand enhances T-Cell migration to the reproductive tract during infection with Chlamydia trachomatis

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Viral characteristics of transmitted HIV.

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5 July 2018

Glycerol monolaurate prevents mucosal SIV transmission

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Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants

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Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies

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5 July 2018

Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1

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5 July 2018

HIV infection of the genital mucosa in women.

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Selection of HIV variants with signature genotypic characteristics during heterosexual transmission

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Human immunodeficiency virus type 1 population genetics and adaptation in newly infected individuals.

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Mammalian glycosylation in immunity

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Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

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Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses

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HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

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Roles of HIV-1 Env variable regions in viral neutralization and vaccine development

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Prospects of HIV Env modification as an approach to HIV vaccine design

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Glycoprotein structural genomics: solving the glycosylation problem

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Structural definition of a conserved neutralization epitope on HIV-1 gp120

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Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity

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Factors determining the breadth and potency of neutralization by V3-specific human monoclonal antibodies derived from subjects infected with clade A or clade B strains of human immunodeficiency virus type 1

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Ancestral and consensus envelope immunogens for HIV-1 subtype C.

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Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1

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Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant

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Perils at mucosal front lines for HIV and SIV and their hosts

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Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope

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Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels

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Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda

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Massive infection and loss of memory CD4 T cells in multiple tissues during acute SIV infection

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Multiple V1/V2 env variants are frequently present during primary infection with human immunodeficiency virus type 1

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The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infection

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Antibody neutralization and escape by HIV-1

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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

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5 July 2018

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1 reference

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5 July 2018

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1 reference

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5 July 2018

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1 reference

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21 January 2018

Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PPAT.1001301

21 January 2018

Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs.

1 reference

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21 January 2018

Distinct roles of L-selectin and integrins alpha 4 beta 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PPAT.1001301

21 January 2018

Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies

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https://api.crossref.org/works/10.1371/JOURNAL.PPAT.1001301

21 January 2018

Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4 T Cells

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21 January 2018

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

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Peak SIV replication in resting memory CD4 T cells depletes gut lamina propria CD4 T cells.

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29 October 2018

Cryoelectron tomographic analysis of an HIV-neutralizing protein and its complex with native viral gp120

1 reference

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12 December 2020

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Levels of N-linked glycosylation on the V1 loop of HIV-1 Env proteins and their relationship to the antigenicity of Env from primary viral isolates

1 reference

https://pubmed.ncbi.nlm.nih.gov/21383973

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PPAT.1001301

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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