Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade (Q33835454)

27789795

29 July 2017

title

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade (English)

1 reference

29 July 2017

12

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3 June 2020

Jason M Schenkel

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Shelley L. Berger

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W Nicholas Haining

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E John Wherry

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author name string

Kristen E Pauken

1

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Morgan A Sammons

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Pamela M Odorizzi

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Sasikanth Manne

4

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Jernej Godec

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Omar Khan

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Adam M Drake

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Zeyu Chen

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Debattama R Sen

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Makoto Kurachi

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R Anthony Barnitz

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Bertram Bengsch

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Alexander C Huang

14

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Golnaz Vahedi

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language of work or name

English

0 references

publication date

27 October 2016

1 reference

29 July 2017

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volume

354

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issue

6316

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page(s)

1160-1165

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T Cell Factor 1-Expressing Memory-like CD8( ) T Cells Sustain the Immune Response to Chronic Viral Infections

3 June 2020

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Molecular and cellular insights into T cell exhaustion

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Epigenetic manipulation restores functions of defective CD8⁺ T cells from chronic viral infection

28 July 2018

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

28 July 2018

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Network analysis reveals centrally connected genes and pathways involved in CD8 T cell exhaustion versus memory.

28 July 2018

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Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation

28 July 2018

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Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8 T cell responses during chronic infection.

28 July 2018

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Immunotherapeutic effects of IL-7 during a chronic viral infection in mice

28 July 2018

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Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

28 July 2018

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NFATc1 regulates PD-1 expression upon T cell activation.

28 July 2018

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Restoring function in exhausted CD8 T cells during chronic viral infection

28 July 2018

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Antigen-independent memory CD8 T cells do not develop during chronic viral infection

28 July 2018

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Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8( ) T Cell Exhaustion

21 January 2018

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21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27789795

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12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.AAF2807

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3 June 2020

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3 June 2020

27789795

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