Rationale for B cell targeting in SLE (Q33829700)

29 July 2017

title

Rationale for B cell targeting in SLE (English)

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29 July 2017

1

Iñaki Sanz

1 reference

29 July 2017

publication date

25 April 2014

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Seminars in Immunopathology

29 July 2017

published in

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29 July 2017

volume

36

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29 July 2017

issue

3

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29 July 2017

page(s)

365-375

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Anti-B cell antibody therapies for inflammatory rheumatic diseases

29 July 2017

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4 July 2018

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4 July 2018

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4 July 2018

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Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response

4 July 2018

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Atacicept in combination with MMF and corticosteroids in lupus nephritis: results of a prematurely terminated trial.

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways

4 July 2018

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Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM.

4 July 2018

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Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

4 July 2018

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Salivary anti-Ro60 and anti-Ro52 Antibody Profiles to Diagnose Sjögren’s Syndrome

4 July 2018

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B cell immunotherapy in autoimmunity – 2010 update

4 July 2018

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Targeting B cells for the treatment of SLE: the beginning of the end or the end of the beginning?

4 July 2018

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Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus.

4 July 2018

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Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.

4 July 2018

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Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data

4 July 2018

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Rituximab versus cyclophosphamide for ANCA-associated vasculitis

4 July 2018

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B cells as therapeutic targets in SLE.

4 July 2018

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B cell therapies for rheumatoid arthritis: beyond B cell depletion

4 July 2018

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Indications of rituximab in autoimmune diseases

4 July 2018

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CD19( )CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Dysregulation of germinal centres in autoimmune disease.

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Current status on B-cell depletion therapy in autoimmune diseases other than rheumatoid arthritis

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Novel human transitional B cell populations revealed by B cell depletion therapy

4 July 2018

1 reference

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Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets

4 July 2018

1 reference

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B cells and immunological tolerance.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Altered B cell receptor signaling in human systemic lupus erythematosus

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

A regulatory B cell subset with a unique CD1dhiCD5 phenotype controls T cell-dependent inflammatory responses

4 July 2018

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Not always the bad guys: B cells as regulators of autoimmune pathology

4 July 2018

1 reference

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Cytokine-producing B lymphocytes-key regulators of immunity

4 July 2018

1 reference

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Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab

4 July 2018

1 reference

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B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Novel suppressive function of transitional 2 B cells in experimental arthritis

4 July 2018

1 reference

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Competence and competition: the challenge of becoming a long-lived plasma cell

4 July 2018

1 reference

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Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

4 July 2018

1 reference

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B cell immunobiology in disease: evolving concepts from the clinic

4 July 2018

1 reference

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Characterization of marginal zone B cell precursors

4 July 2018

1 reference

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Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.

4 July 2018

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Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?

4 July 2018

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Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells

4 July 2018

1 reference

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TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production.

4 July 2018

1 reference

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

4 July 2018

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Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease

4 July 2018

1 reference

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Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis

4 July 2018

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Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

B cells regulate autoimmunity by provision of IL-10.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

VH4-34 encoded antibodies in systemic lupus erythematosus: a specific diagnostic marker that correlates with clinical disease characteristics

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Long-term follow-up of autoantibody profiles in black female lupus patients and clinical comparison with Caucasian and Asian patients

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology

4 July 2018

1 reference

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Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

CD19 CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation

4 July 2018

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https://api.crossref.org/works/10.1007/S00281-014-0430-Z

Identification of anergic B cells within a wild-type repertoire.

21 January 2018

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Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus.

21 January 2018

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A human equivalent of mouse B-1 cells?

21 January 2018

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To B1 or not to B1: that really is still the question!

21 January 2018

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Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.

21 January 2018

1 reference

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Tipping the scales of selection with BAFF.

21 January 2018

1 reference

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Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts

21 January 2018

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Multiple layers of B cell memory with different effector functions

21 January 2018

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Maintenance of serological memory by polyclonal activation of human memory B cells

21 January 2018

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Multiparameter flow cytometry and bioanalytics for B cell profiling in systemic lupus erythematosus

21 January 2018

1 reference

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Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00281-014-0430-Z

B cell biomarkers of rituximab responses in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00281-014-0430-Z

Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00281-014-0430-Z

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00281-014-0430-Z

Phenotypic Changes of Lymphocytes in Patients with Systemic Lupus Erythematosus Who Are in Longterm Remission After B Cell Depletion Therapy with Rituximab

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077421

The anti-CD20 antibody rituximab reduces the Th17 cell response

29 October 2018

1 reference

https://api.crossref.org/works/10.1007/S00281-014-0430-Z

Differential effects of epratuzumab on peripheral blood B cells of patients with systemic lupus erythematosus versus normal controls

21 January 2018

1 reference

12 December 2020

Generation of peripheral B cells occurs via two spatially and temporally distinct pathways

1 reference

12 December 2020

Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells

1 reference

12 December 2020

Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95

1 reference

12 December 2020

B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab

1 reference

12 December 2020

IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells

1 reference

12 December 2020

Cutting edge: primary B lymphocytes preferentially expand allogeneic FoxP3 CD4 T cells

1 reference

12 December 2020

Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus

1 reference

12 December 2020

A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells

1 reference

12 December 2020

Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy

1 reference

12 December 2020

B cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles

1 reference

12 December 2020

Reciprocal regulation of polarized cytokine production by effector B and T cells

1 reference

12 December 2020

Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER)

1 reference

12 December 2020

The landscape after LUNAR: Rituximab's crater‐filled path

1 reference

12 December 2020

A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus

1 reference

12 December 2020

10.1007/S00281-014-0430-Z

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29 July 2017

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29 July 2017

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