New molecular targets in radiotherapy: DNA damage signalling and repair in targeted and non-targeted cells (Q33794733)

29 July 2017

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title

New molecular targets in radiotherapy: DNA damage signalling and repair in targeted and non-targeted cells (English)

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adaptive radiation therapy

29 July 2017

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author name string

Susanne Burdak-Rothkamm

series ordinal

1

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29 July 2017

Kevin M Prise

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

14 October 2009

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European Journal of Pharmacology

29 July 2017

published in

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29 July 2017

volume

625

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29 July 2017

issue

1-3

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29 July 2017

page(s)

151-155

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

29 July 2017

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of [...]

4 July 2018

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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

4 July 2018

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A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Inhibition of poly(ADP-ribose) polymerase in cancer

4 July 2018

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4 July 2018

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Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

4 July 2018

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Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

4 July 2018

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Induction of replication protein A in bystander cells

4 July 2018

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Enhancement of radiation cytotoxicity by UCN-01 in non-small cell lung carcinoma cells

4 July 2018

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Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells

4 July 2018

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Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Inhibitory targeting of checkpoint kinase signaling overrides radiation-induced cell cycle gene regulation: a therapeutic strategy in tumor cell radiosensitization?

4 July 2018

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Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.

4 July 2018

1 reference

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A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

4 July 2018

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Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

4 July 2018

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Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Radiation-induced bystander effects, carcinogenesis and models

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor

4 July 2018

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Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells

4 July 2018

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ATM as a target for novel radiosensitizers

4 July 2018

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Studies of bystander effects in human fibroblasts using a charged particle microbeam

4 July 2018

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Initial events in the cellular effects of ionizing radiations: clustered damage in DNA.

4 July 2018

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PARP inhibitors and cancer therapy - early results and potential applications

4 July 2018

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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

30 October 2018

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The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

30 October 2018

1 reference

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Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relocalization in irradiated and bystander cells.

30 October 2018

1 reference

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Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

The time and spatial effects of bystander response in mammalian cells induced by low dose radiation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Involvement of membrane signaling in the bystander effect in irradiated cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855957

Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19835868

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19835868

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.EJPHAR.2009.09.068

1 reference

29 July 2017

1 reference

29 July 2017

1 reference