Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease (Q33793485)

29 July 2017

title

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease (English)

1 reference

Complement component 5a receptor 1

29 July 2017

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GOA release 2020-03-11

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Trent M Woodruff

8

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author name string

Maria I Fonseca

1

1 reference

29 July 2017

Rahasson R Ager

2

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29 July 2017

Shu-Hui Chu

3

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29 July 2017

Ozkan Yazan

4

1 reference

29 July 2017

Sam D Sanderson

5

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29 July 2017

Frank M LaFerla

6

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29 July 2017

Stephen M Taylor

7

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29 July 2017

Andrea J Tenner

9

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29 July 2017

language of work or name

English

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publication date

26 June 2009

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29 July 2017

published in

Journal of Immunology

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29 July 2017

volume

183

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29 July 2017

issue

2

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29 July 2017

page(s)

1375-1383

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Frequent amyloid deposition without significant cognitive impairment among the elderly

29 July 2017

cites work

1 reference

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Role of toll-like receptor signalling in Abeta uptake and clearance

4 July 2018

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

4 July 2018

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Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease

4 July 2018

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Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties

4 July 2018

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Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease

4 July 2018

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Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist.

4 July 2018

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C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism

4 July 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

4 July 2018

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A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug

4 July 2018

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Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

4 July 2018

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4 July 2018

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Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

4 July 2018

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Inflammation and Alzheimer's disease

4 July 2018

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4 July 2018

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Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide

4 July 2018

1 reference

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Inflammatory signals induce neurotrophin expression in human microglial cells

4 July 2018

1 reference

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Microglial response to amyloid plaques in APPsw transgenic mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Localization and cell association of C1q in Alzheimer's disease brain

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Chemotaxis by a CNS macrophage, the microglia

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Concurrent muscarinic and beta-adrenergic blockade in rats impairs place-learning in a water maze and retention of inhibitory avoidance

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Complement activation by beta-amyloid in Alzheimer disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Plaque complement activation and cognitive loss in Alzheimer's disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Complement activation in very early Alzheimer disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

C5a negatively regulates toll-like receptor 4-induced immune responses

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Increased serum C3 levels in Crry transgenic mice partially abrogates its complement inhibitory effects

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Modulatory role of cyclooxygenase inhibitors in aging- and scopolamine or lipopolysaccharide-induced cognitive dysfunction in mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Complement activation by neurofibrillary tangles in Alzheimer's disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067320

In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata

30 October 2018

1 reference

12 December 2020

Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats

1 reference

12 December 2020

Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton

1 reference

12 December 2020

The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Pathological tau: a loss of normal function or a gain in toxicity?

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0901005

1 reference

29 July 2017

1 reference

29 July 2017

1 reference