Progress in antisense technology: the end of the beginning (Q33792920)

29 July 2017

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title

Progress in antisense technology: the end of the beginning (English)

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29 July 2017

Crooke ST

1

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29 July 2017

language of work or name

English

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publication date

1 January 2000

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29 July 2017

published in

Methods in Enzymology

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29 July 2017

volume

313

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29 July 2017

page(s)

3-45

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Implication of RNA structure on antisense oligonucleotide hybridization kinetics

29 July 2017

cites work

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7 January 2021

Pseudo--half-knot formation with RNA

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A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts.

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7 January 2021

Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region

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7 January 2021

Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide

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7 January 2021

Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer

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7 January 2021

In vitro evaluation of phosphorothioate oligonucleotides targeted to the E2 mRNA of papillomavirus: potential treatment for genital warts

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7 January 2021

Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element

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7 January 2021

Selective inhibition of the cytopathic effect of type A influenza viruses by oligodeoxynucleotides covalently linked to an intercalating agent

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7 January 2021

Complementary oligodeoxynucleotide mediated inhibition of tobacco mosaic virus RNA translation in vitro

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7 January 2021

Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length

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7 January 2021

Site specific enzymatic cleavage of RNA

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7 January 2021

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

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7 January 2021

Highly efficient chemical synthesis of 2'-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or DNA specific nucleases.

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7 January 2021

Alpha-DNA.IX: Parallel annealing of alpha-anomeric oligodeoxyribonucleotides to natural mRNA is required for interference in RNase H mediated hydrolysis and reverse transcription.

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7 January 2021

Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation

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7 January 2021

Antisense oligonucleotides as therapeutic agents--is the bullet really magical?

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7 January 2021

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

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7 January 2021

Number and distribution of methylphosphonate linkages in oligodeoxynucleotides affect exo- and endonuclease sensitivity and ability to form RNase H substrates

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7 January 2021

RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds

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7 January 2021

Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures

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7 January 2021

The use of single-stranded DNA and RNase H to promote quantitative 'hybrid arrest of translation' of mRNA/DNA hybrids in reticulocyte lysate cell-free translations

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7 January 2021

alpha-DNA. VI: Comparative study of alpha- and beta-anomeric oligodeoxyribonucleotides in hybridization to mRNA and in cell free translation inhibition

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Detection of ribonuclease H-generated mRNA fragments in human leukemia cells following reversible membrane permeabilization in the presence of antisense oligodeoxynucleotides.

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

The Influence of Antisense Oligonucleotide-induced RNA Structure on Escherichia coli RNase H1 Activity

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Molecular Cloning and Expression of cDNA for Human RNase H

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Progress toward oligonucleotide therapeutics: pharmacodynamic properties

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridization sites on structured RNA.

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7 January 2021

A rapid in vitro method for obtaining RNA accessibility patterns for complementary DNA probes: correlation with an intracellular pattern and known RNA structures

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Interferon Induction Increased through Chemical Modification of a Synthetic Polyribonucleotide

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7 January 2021

Therapeutic applications of oligonucleotides

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7 January 2021

Therapeutic Applications of Oligonucleotides

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7 January 2021

Interaction of oligodeoxynucleotides with mammalian cells

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide

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7 January 2021

Oligodeoxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: dependence on phosphorothioate modification and reversal by heparin.

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Tritium labeling of antisense oligonucleotides by exchange with tritiated water

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7 January 2021

Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection

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7 January 2021

Oligodeoxynucleotide stability in subcellular extracts and culture media

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7 January 2021

Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid

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7 January 2021

Stability and Pharmacokinetic Characteristics of Oligonucleotides Modified at Terminal Linkages in Mice

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7 January 2021

Internalization of oligodeoxyribonucleotides by Vibrio parahaemolyticus

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7 January 2021

Uptake, Intracellular Distribution, and Stability of Oligodeoxynucleotide Phosphorothioate by Schistosoma mansoni

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7 January 2021

Transport of phosphorothioate oligonucleotides in kidney: Implications for molecular therapy

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7 January 2021

Systemic administration of a phosphorothioate oligonucleotide with a sequence complementary to p53 for acute myelogenous leukemia and myelodysplastic syndrome: initial results of a phase I trial

1 reference

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7 January 2021

Pharmacokinetics of an anti—human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects*

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7 January 2021

Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system

1 reference

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7 January 2021

Radiolabeling of methylphosphonate and phosphorothioate oligonucleotides and evaluation of their transport in everted rat jejunum sacs

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Inhibition of interferon-gamma-induced intercellular adhesion molecule-1 expression on human keratinocytes by phosphorothioate antisense oligodeoxynucleotides is the consequence of antisense-specific and antisense-non-specific effects

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Suppression of neointimal smooth muscle cell accumulation in vivo by antisense cdc2 and cdk2 oligonucleotides in rat carotid artery

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Antisense oligodeoxynucleotide inhibits D2 dopamine receptor-mediated behavior and D2 messenger RNA.

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

A decrease in angiotensin receptor binding in rat brain nuclei by antisense oligonucleotides to the angiotensin AT1 receptor.

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Antisense oligonucleotide inhibition of tryptophan hydroxylase activity in mouse brain

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

DNA antisense therapy for asthma in an animal model

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Oligonucleotides antisense to the interleukin 1 receptor mRNA block the effects of interleukin 1 in cultured murine and human fibroblasts and in mice

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Nuclease resistance and antisense activity of modified oligonucleotides targeted to Ha-ras

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Oligonucleotide sequences required for natural killer cell activation

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Effect of antisense oligonucleotides on cytokine release from human keratinocytes in an in vitro model of skin

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

CpG motifs in bacterial DNA trigger direct B-cell activation

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Comparison of the toxicity profiles of ISIS 1082 and ISIS 2105, phosphorothioate oligonucleotides, following subacute intradermal administration in Sprague-Dawley rats

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Evaluation of the Toxicity of ISIS 2302, a Phosphorothioate Oligonucleotide, in a 4-Week Study in CD-1 Mice

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Inhibition of Coagulation by a Phosphorothioate Oligonucleotide

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Synthesis and hybridization of dodecadeoxyribonucleotides containing a fluorescent pyridopyrimidine deoxynucleoside

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

New synthetic routes to synthons suitable for 2′-O-allyloligoribonucleotide assembly

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Base pairing involving deoxyinosine: implications for probe design

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Pharmacokinetics, biodistribution, and stability of capped oligodeoxynucleotide phosphorothioates in mice

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Efficient sequence-specific cleavage of RNA using novel europium complexes conjugated to oligonucleotides

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Cholesteryl-conjugated phosphorothioate oligodeoxynucleotides modulate CYP2B1 expression in vivo

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Antisense oligonucleotides made of 2'-O-alkylRNA: their properties and applications in RNA biochemistry

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Antisense and Antigene Properties of Peptide Nucleic Acids

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https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

Characterization of Binding Sites, Extent of Binding, and Drug Interactions of Oligonucleotides with Albumin

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

In Vivo Modulation of N-myc Expression by Continuous Perfusion with an Antisense Oligonucleotide

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(00)13003-4

7 January 2021

10.1016/S0076-6879(00)13003-4

Identifiers

DOI

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29 July 2017

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