Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms (Q33791610)

29 July 2017

title

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms (English)

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29 July 2017

23

Aviv Regev

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29 July 2017

Chuan Wu

7

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David A. Hafler

22

object named as

David A Hafler

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29 July 2017

20

Richard A Young

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26

Vijay K Kuchroo

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29 July 2017

Sheng Xiao

1

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Nir Yosef

2

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29 July 2017

Jianfei Yang

3

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29 July 2017

Yonghui Wang

4

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29 July 2017

Ling Zhou

5

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29 July 2017

Chen Zhu

6

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29 July 2017

Erkan Baloglu

8

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Darby Schmidt

9

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Radha Ramesh

10

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Mercedes Lobera

11

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29 July 2017

Mark S Sundrud

12

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29 July 2017

Pei-Yun Tsai

13

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29 July 2017

Zhijun Xiang

14

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29 July 2017

Jinsong Wang

15

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Yan Xu

16

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29 July 2017

Xichen Lin

17

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Karsten Kretschmer

18

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Peter B Rahl

19

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Zhong Zhong

21

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Shomir Ghosh

24

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29 July 2017

Alexander Marson

25

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29 July 2017

language of work or name

English

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publication date

1 April 2014

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29 July 2017

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29 July 2017

volume

40

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29 July 2017

issue

4

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29 July 2017

page(s)

477-489

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Dynamic regulatory network controlling TH17 cell differentiation

29 July 2017

cites work

1 reference

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Effect of IL-17A blockade with secukinumab in autoimmune diseases

4 July 2018

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T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.

4 July 2018

1 reference

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A validated regulatory network for Th17 cell specification

4 July 2018

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A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes

4 July 2018

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Induction and molecular signature of pathogenic TH17 cells

4 July 2018

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Effector CD4 T cell expression signatures and immune-mediated disease associated genes

4 July 2018

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Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

4 July 2018

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Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types

4 July 2018

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Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human

4 July 2018

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Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

4 July 2018

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Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

4 July 2018

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New IBD genetics: common pathways with other diseases.

4 July 2018

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Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

4 July 2018

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LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

4 July 2018

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Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

4 July 2018

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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

4 July 2018

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The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

4 July 2018

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Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways

4 July 2018

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Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4 T cells

4 July 2018

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4 July 2018

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Retinoic acid increases Foxp3 regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression

4 July 2018

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The genetics and immunopathogenesis of inflammatory bowel disease

4 July 2018

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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

4 July 2018

1 reference

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Foxp3 occupancy and regulation of key target genes during T-cell stimulation

4 July 2018

1 reference

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Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

4 July 2018

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 T helper cells

4 July 2018

1 reference

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

4 July 2018

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

4 July 2018

1 reference

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Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

4 July 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24745332

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24745332

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.IMMUNI.2014.04.004

1 reference

29 July 2017

1 reference

29 July 2017

1 reference