Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3 (Q33789758)

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English	Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3	scientific article

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19 January 2020

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3 (English)

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19 January 2020

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19 January 2020

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19 January 2020

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19 January 2020

Graeme Milligan

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Graeme Milligan

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19 January 2020

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Johannes Schmidt

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19 January 2020

Elisabeth Christiansen

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19 January 2020

Irina G Tikhonova

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19 January 2020

Manuel Grundmann

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19 January 2020

Richard J Ward

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19 January 2020

Christel Drewke

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19 January 2020

Evi Kostenis

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10 January 2011

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19 January 2020

Journal of Biological Chemistry

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19 January 2020

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19 January 2020

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19 January 2020

10628-10640

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19 January 2020

When simple agonism is not enough: emerging modalities of GPCR ligands.

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Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation

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GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

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4 July 2018

Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3.

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International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions

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Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

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Functional selectivity in GPCR modulator screening

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Ligand efficiency: a useful metric for lead selection

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Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

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Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

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PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

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A holistic view of GPCR signaling

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https://pubmed.ncbi.nlm.nih.gov/21220428

12 December 2020

based on heuristic

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10.1074/JBC.M110.210872

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19 January 2020

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19 January 2020

PubMed publication ID

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19 January 2020

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