Use of Genetically Altered Stem Cells for the Treatment of Huntington's Disease (Q33788929)

29 July 2017

title

Use of Genetically Altered Stem Cells for the Treatment of Huntington's Disease (English)

1 reference

29 July 2017

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Julien Rossignol

2

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author name string

Andrew T Crane

series ordinal

1

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29 July 2017

Gary L Dunbar

series ordinal

3

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29 July 2017

publication date

24 March 2014

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29 July 2017

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29 July 2017

volume

4

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29 July 2017

issue

1

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29 July 2017

page(s)

202-219

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Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

24 March 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Transplants of adult mesenchymal and neural stem cells provide neuroprotection and behavioral sparing in a transgenic rat model of Huntington's disease

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Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease

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Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease.

4 July 2018

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Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells

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Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells

4 July 2018

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Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin

4 July 2018

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Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease

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Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models.

4 July 2018

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Milestones in huntington disease

4 July 2018

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Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway.

4 July 2018

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Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1

4 July 2018

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BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice

4 July 2018

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Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells

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4 July 2018

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4 July 2018

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Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

4 July 2018

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BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.

4 July 2018

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Neural grafts in Huntington's disease: viability after 10 years

4 July 2018

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Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

4 July 2018

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Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration

4 July 2018

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4 July 2018

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Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats.

4 July 2018

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Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity

4 July 2018

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Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin

4 July 2018

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4 July 2018

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Intercellular transfer mediated by tunneling nanotubes

4 July 2018

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Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Blood-brain barrier delivery

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Mitochondrial transfer between cells can rescue aerobic respiration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Onset and rate of striatal atrophy in preclinical Huntington disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Multipotent cell lineages in early mouse development depend on SOX2 function

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Anterograde transport of brain-derived neurotrophic factor and its role in the brain

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: studies in vivo and in vitro

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Inactivation of the mouse Huntington's disease gene homolog Hdh

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Neuropathological classification of Huntington's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Fibroblast precursors in normal and irradiated mouse hematopoietic organs

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease

4 July 2018

1 reference

https://api.crossref.org/works/10.3390/BRAINSCI4010202

Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial

21 January 2018

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https://api.crossref.org/works/10.3390/BRAINSCI4010202

Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/BRAINSCI4010202

Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/BRAINSCI4010202

Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/BRAINSCI4010202

Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/BRAINSCI4010202

Dormant phase and multinuclear cells: two key phenomena in early culture of murine bone marrow mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/BRAINSCI4010202

Autologous adult bone marrow stem cell transplantation in an animal model of huntington's disease: behavioral and morphological outcomes

21 January 2018

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https://api.crossref.org/works/10.3390/BRAINSCI4010202

Stem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.3390/BRAINSCI4010202

Mesenchymal stem cell transplantation and DMEM administration in a 3NP rat model of Huntington's disease: morphological and behavioral outcomes

21 January 2018

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https://api.crossref.org/works/10.3390/BRAINSCI4010202

Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.3390/BRAINSCI4010202

Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/BRAINSCI4010202

Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/BRAINSCI4010202

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/BRAINSCI4010202

Mesenchymal stem cells induce a weak immune response in the rat striatum after allo or xenotransplantation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

Long-term follow-up of metabolic activity in human alveolar echinococcosis using FDG-PET.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066244

30 October 2018

Identifiers

DOI

10.3390/BRAINSCI4010202

1 reference

29 July 2017

1 reference

29 July 2017

1 reference