Genome-wide association studies: progress and potential for drug discovery and development (Q33784699)

29 July 2017

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title

Genome-wide association studies: progress and potential for drug discovery and development (English)

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genome-wide association study

29 July 2017

main subject

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1 reference

Stephen F Kingsmore

1

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author name string

Ingrid E Lindquist

2

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29 July 2017

Joann Mudge

3

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29 July 2017

Damian D Gessler

4

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29 July 2017

William D Beavis

5

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29 July 2017

publication date

1 March 2008

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Nature Reviews Drug Discovery

29 July 2017

published in

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29 July 2017

volume

7

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29 July 2017

issue

3

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29 July 2017

page(s)

221-230

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Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

29 July 2017

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer

4 July 2018

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A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

4 July 2018

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Genome-wide association study identifies novel breast cancer susceptibility loci

4 July 2018

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Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans

4 July 2018

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Variation in FTO contributes to childhood obesity and severe adult obesity

4 July 2018

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Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations

4 July 2018

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The role of HLA class I gene variation in autoimmune diabetes

4 July 2018

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A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

4 July 2018

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

4 July 2018

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

4 July 2018

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

4 July 2018

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4 July 2018

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Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

4 July 2018

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4 July 2018

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4 July 2018

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Multiple regions within 8q24 independently affect risk for prostate cancer

4 July 2018

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Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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A genome-wide association study identifies novel risk loci for type 2 diabetes

4 July 2018

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A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

4 July 2018

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

4 July 2018

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Novel genes identified in a high-density genome wide association study for nicotine dependence

4 July 2018

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The Type 1 Diabetes Genetics Consortium

4 July 2018

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

4 July 2018

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Common Kibra alleles are associated with human memory performance

4 July 2018

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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

4 July 2018

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Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study

4 July 2018

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Genetics of inflammatory bowel disease: the role of the HLA complex

4 July 2018

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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

4 July 2018

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Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C.

4 July 2018

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A common variant associated with prostate cancer in European and African populations

4 July 2018

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A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization

4 July 2018

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Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration

4 July 2018

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

4 July 2018

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CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD

4 July 2018

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A haplotype map of the human genome

4 July 2018

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4 July 2018

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Identification of four gene variants associated with myocardial infarction

4 July 2018

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Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration

4 July 2018

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A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

4 July 2018

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Complement factor H polymorphism in age-related macular degeneration

4 July 2018

1 reference

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A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases.

4 July 2018

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Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

4 July 2018

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Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework

4 July 2018

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Replication in genetic studies of complex traits.

4 July 2018

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Regulatory polymorphisms underlying complex disease traits

4 July 2018

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TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

4 July 2018

1 reference

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Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: evolutionary evidence for differences in molecular effects.

4 July 2018

1 reference

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The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology

4 July 2018

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Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

4 July 2018

1 reference

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Nonreplication in Genetic Association Studies of Obesity and Diabetes Research

4 July 2018

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Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element

4 July 2018

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Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

4 July 2018

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Population stratification and spurious allelic association

4 July 2018

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Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

4 July 2018

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Haplotype block structure and its applications to association studies: power and study designs

4 July 2018

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The allelic architecture of human disease genes: common disease-common variant... or not?

4 July 2018

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A comprehensive review of genetic association studies

4 July 2018

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Replication validity of genetic association studies

4 July 2018

1 reference

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Large upward bias in estimation of locus-specific effects from genomewide scans

4 July 2018

1 reference

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On the allelic spectrum of human disease

4 July 2018

1 reference

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Haplotype variation and linkage disequilibrium in 313 human genes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Are rare variants responsible for susceptibility to complex diseases?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

4 July 2018

1 reference

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Association study designs for complex diseases

4 July 2018

1 reference

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dbSNP: the NCBI database of genetic variation

4 July 2018

1 reference

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Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

4 July 2018

1 reference

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Searching for genetic determinants in the new millennium

4 July 2018

1 reference

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Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

4 July 2018

1 reference

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Drinking from the fire hose--statistical issues in genomewide association studies

4 July 2018

1 reference

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Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

30 October 2018

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Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

30 October 2018

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A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease

30 October 2018

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Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

30 October 2018

1 reference

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KIBRA gene variants are associated with episodic memory in healthy elderly.

30 October 2018

1 reference

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Genetic basis of rheumatoid arthritis

30 October 2018

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Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

A Polymorphism in the Protease-Like Domain of Apolipoprotein(a) Is Associated With Severe Coronary Artery Disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Diabetes and Risk of Prostate Cancer in a Prospective Cohort of US Men

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853477

Population genetics--making sense out of sequence

30 October 2018

1 reference

Conjuring SNPs to detect associations

31 March 2020

1 reference

Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction

31 March 2020

1 reference

Guilt beyond a reasonable doubt

31 March 2020

1 reference

Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18274536

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD2519

1 reference

release_qmfjopqnifd2nedraloiurgqva

29 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qmfjopqnifd2nedraloiurgqva

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

2853477

1 reference

29 July 2017

1 reference