Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4. (Q33780620)

29 July 2017

title

Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4. (English)

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29 July 2017

9

Robert J Gorelick

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29 July 2017

3

Joseph W Adelsberger

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29 July 2017

Quan-En Yang

1

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29 July 2017

Andrew G Stephen

2

1 reference

29 July 2017

Paula E Roberts

4

1 reference

29 July 2017

Weimin Zhu

5

1 reference

29 July 2017

Michael J Currens

6

1 reference

29 July 2017

Yaxiong Feng

7

1 reference

29 July 2017

Bruce J Crise

8

1 reference

29 July 2017

Alan R Rein

10

1 reference

29 July 2017

Robert J Fisher

11

1 reference

29 July 2017

Robert H Shoemaker

12

1 reference

29 July 2017

Shizuko Sei

13

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29 July 2017

publication date

1 May 2005

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29 July 2017

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29 July 2017

volume

79

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29 July 2017

issue

10

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29 July 2017

page(s)

6122-6133

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Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions

29 July 2017

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4 July 2018

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4 July 2018

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Human immunodeficiency virus type 1 nucleocapsid zn(2 ) fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA.

4 July 2018

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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

4 July 2018

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Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity

4 July 2018

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Direct comparison of binding equilibrium, thermodynamic, and rate constants determined by surface- and solution-based biophysical methods

4 July 2018

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4 July 2018

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SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

4 July 2018

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Structural flexibility and functional valence of CD4-IgG2 (PRO 542): potential for cross-linking human immunodeficiency virus type 1 envelope spikes

4 July 2018

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Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein

4 July 2018

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Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates

4 July 2018

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Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

4 July 2018

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A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

4 July 2018

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Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain

4 July 2018

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Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120

4 July 2018

1 reference

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Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein

4 July 2018

1 reference

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Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket

4 July 2018

1 reference

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Effects of soluble CD4 on simian immunodeficiency virus infection of CD4-positive and CD4-negative cells

4 July 2018

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Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency

4 July 2018

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A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

4 July 2018

1 reference

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Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies

4 July 2018

1 reference

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

4 July 2018

1 reference

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Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replication

4 July 2018

1 reference

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Sequence-Specific Binding of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein to Short Oligonucleotides

4 July 2018

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Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

4 July 2018

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Core structure of gp41 from the HIV envelope glycoprotein

4 July 2018

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Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection

4 July 2018

1 reference

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Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.

4 July 2018

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The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent

4 July 2018

1 reference

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Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4.

4 July 2018

1 reference

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Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells

4 July 2018

1 reference

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A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Isolation of Epstein-Barr virus (EBV)-negative cell clones from the EBV-positive Burkitt's lymphoma (BL) line Akata: malignant phenotypes of BL cells are dependent on EBV

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid)

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Selective extraction of polyoma DNA from infected mouse cell cultures

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

A soluble form of CD4 (T4) protein inhibits AIDS virus infection

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Soluble CD4 molecules neutralize human immunodeficiency virus type 1.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

HIV infection is blocked in vitro by recombinant soluble CD4.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Identification of the residues in human CD4 critical for the binding of HIV.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

New soluble-formazan assay for HIV-1 cytopathic effects: application to high-flux screening of synthetic and natural products for AIDS-antiviral activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Synchronous and sequential activation of latently infected Epstein-Barr virus genomes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Recombinant soluble CD4 therapy in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase I-II escalating dosage trial

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

A bioassay for HIV-1 based on Env-CD4 interaction

4 July 2018

1 reference

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Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

4 July 2018

1 reference

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Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight

4 July 2018

1 reference

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Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.

4 July 2018

1 reference

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Selective inhibitory activity of polyhydroxycarboxylates derived from phenolic compounds against human immunodeficiency virus replication

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1091715

Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

4 July 2018

1 reference

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Sulfonic acid polymers as a new class of human immunodeficiency virus inhibitors

4 July 2018

1 reference

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Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia

4 July 2018

1 reference

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Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes

30 October 2018

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Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies

30 October 2018

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Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults

30 October 2018

1 reference

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Isolation, Primary Sequence Determination, and Disulfide Bond Structure of Cyanovirin-N, an Anti-HIV(Human Immunodeficiency Virus) Protein from the CyanobacteriumNostoc ellipsosporum

30 October 2018

1 reference

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A trimeric structural domain of the HIV-1 transmembrane glycoprotein.

30 October 2018

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A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

30 October 2018

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12 December 2020

Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors

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12 December 2020

Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen

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12 December 2020

Enhancement of infectivity of a non-syncytium inducing HIV-1 by sCD4 and by human antibodies that neutralize syncytium inducing HIV-1

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12 December 2020

Epitopes of the CD4 antigen and HIV infection

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12 December 2020

Evidence and prevention of HIV-1 nucleocapsid protein adsorption onto fluorescence quartz cells

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12 December 2020

10.1128/JVI.79.10.6122-6133.2005

Identifiers

DOI

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29 July 2017

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29 July 2017

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