A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. (Q33779634)

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30 January 2020

title

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation (English)

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7

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6

Robert J Lefkowitz

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30 January 2020

author name string

Diane Gesty-Palmer

1

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30 January 2020

Pat Flannery

2

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Ling Yuan

3

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Leonor Corsino

4

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Robert Spurney

5

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language of work or name

English

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publication date

1 October 2009

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Science Translational Medicine

30 January 2020

published in

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volume

1

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issue

1

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30 January 2020

page(s)

1ra1

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Functional selectivity through protean and biased agonism: who steers the ship?

30 January 2020

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The use of parathyroid hormone in the treatment of osteoporosis

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beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice

4 July 2018

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Parathyroid hormone-dependent signaling pathways regulating genes in bone cells.

4 July 2018

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Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association

4 July 2018

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4 July 2018

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Signaling at zero G: G-protein-independent functions for 7-TM receptors

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Inverse, protean, and ligand-selective agonism: matters of receptor conformation

4 July 2018

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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

4 July 2018

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

4 July 2018

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4 July 2018

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4 July 2018

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Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells

4 July 2018

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Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy

4 July 2018

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3',5'-Cyclic adenosine monophosphate activation in osteoblastic cells: effects on parathyroid hormone-1 receptors and osteoblastic differentiation in vitro

4 July 2018

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4 July 2018

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4 July 2018

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Cloned, stably expressed parathyroid hormone (PTH)/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells

4 July 2018

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4 July 2018

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4 July 2018

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Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis

4 July 2018

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4 July 2018

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Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.

30 October 2018

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Heptahelical terpsichory. Who calls the tune?

30 October 2018

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12 December 2020

Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype

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12 December 2020

Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells

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12 December 2020

Truncation of the amino terminus of PTH alters its anabolic activity on bone in vivo

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12 December 2020

Bone response to intermittent parathyroid hormone is altered in mice null for {beta}-Arrestin2

1 reference

12 December 2020

10.1126/SCITRANSLMED.3000071

Identifiers

DOI

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30 January 2020

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30 January 2020

PubMed publication ID

20368153

1 reference