Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response (Q33778215)

29 July 2017

title

Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response (English)

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29 July 2017

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8

Dafna Bar-Sagi

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29 July 2017

Elda Grabocka

1

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29 July 2017

Yuliya Pylayeva-Gupta

2

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29 July 2017

Mathew J K Jones

3

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29 July 2017

Veronica Lubkov

4

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29 July 2017

Eyoel Yemanaberhan

5

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29 July 2017

Laura Taylor

6

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29 July 2017

Hao Hsuan Jeng

7

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29 July 2017

publication date

1 February 2014

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29 July 2017

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29 July 2017

volume

25

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29 July 2017

issue

2

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29 July 2017

page(s)

243-256

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Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

29 July 2017

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Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling

4 July 2018

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

4 July 2018

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4 July 2018

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Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.

4 July 2018

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P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

4 July 2018

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

4 July 2018

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

4 July 2018

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The combined status of ATM and p53 link tumor development with therapeutic response

4 July 2018

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

4 July 2018

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Principles of cancer therapy: oncogene and non-oncogene addiction

4 July 2018

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Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

4 July 2018

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Tumour maintenance is mediated by eNOS.

4 July 2018

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GEFs and GAPs: critical elements in the control of small G proteins

4 July 2018

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Exercising restraints: role of Chk1 in regulating the onset and progression of unperturbed mitosis in vertebrate cells

4 July 2018

1 reference

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Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Regulation and role of Raf-1/B-Raf heterodimerization

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Antitumour activity of XR8634 in vitro and in vivo in combination with 5-fluorouracil and irinotecan in colon cancer cell lines

4 July 2018

1 reference

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The wild-type Ras: road ahead

4 July 2018

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Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

4 July 2018

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Chk1 is haploinsufficient for multiple functions critical to tumor suppression

4 July 2018

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Inhibition of Chk1 by activated PKB/Akt.

4 July 2018

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Targeting the checkpoint kinases: chemosensitization versus chemoprotection

4 July 2018

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Chk1 and Chk2 kinases in checkpoint control and cancer

4 July 2018

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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Wildtype Kras2 can inhibit lung carcinogenesis in mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Active Ras induces heterodimerization of cRaf and BRaf

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

The DNA damage response: putting checkpoints in perspective

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Formation of the Ras dimer is essential for Raf-1 activation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Essential role for oncogenic Ras in tumour maintenance

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Validating Aurora B as an anti-cancer drug target.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063560

PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24525237

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2014.01.005

1 reference

29 July 2017

1 reference

29 July 2017

1 reference