ATM: a mediator of multiple responses to genotoxic stress (Q33771767)

29 July 2017

1 reference

title

ATM: a mediator of multiple responses to genotoxic stress (English)

1 reference

29 July 2017

1 reference

Rotman G

1

1 reference

29 July 2017

Shiloh Y

series ordinal

2

1 reference

29 July 2017

language of work or name

English

0 references

publication date

1 November 1999

1 reference

29 July 2017

1 reference

29 July 2017

volume

18

1 reference

29 July 2017

issue

45

1 reference

29 July 2017

page(s)

6135-6144

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

29 July 2017

1 reference

Activate NF-kappa B or die?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The DNA-dependent protein kinase participates in the activation of NF kappa B following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

DNA-dependent protein kinase-independent activation of p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The role of ATM in DNA damage responses and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Ionizing radiation-induced phosphorylation of RPA p34 is deficient in ataxia telangiectasia and reduced in aged normal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

21 January 2018

Ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Identification of defective illegitimate recombinational repair of oxidatively-induced DNA double-strand breaks in ataxia-telangiectasia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Cell cycle checkpoints: preventing an identity crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The role of DNA double strand breaks in lonizing radiation-induced killing of eukaryotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

DNA-PK: at the cross-roads of biochemistry and genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Binding of Ku and c-Abl at the Kinase Homology Region of DNA-dependent Protein Kinase Catalytic Subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Correction of radiation sensitivity in ataxia telangiectasia cells by a truncated I kappa B-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Expression of a dominant negative IκB-α modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Molecular mechanisms of DNA double strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The regulation of AP-1 activity by mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Functional interaction between DNA-PK and c-Abl in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Radiation effects on DNA synthesis in a defined chromosomal replicon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The genetic defect in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Radiosensitivity and oxidative signalling in ataxia telangiectasia: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Impaired ionizing radiation-induced activation of a nuclear signal essential for phosphorylation of c-Jun by dually phosphorylated c-Jun amino-terminal kinases in ataxia telangiectasia fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Three distinct signalling responses by murine fibroblasts to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Regulation of the cell cycle following DNA damage in normal and Ataxia telangiectasia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Catalysis by a Multiprotein IκB Kinase Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Multisite phosphorylation and the integration of stress signals at p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Accelerated telomere shortening in ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Mdm-2: "big brother" of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Checkpoint Pathways Come of Age

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Radiosensitivity in ataxia-telangiectasia: a new explanation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Evidence of a chromatin basis for increased mutagen sensitivity associated with multiple primary malignancies of the head and neck

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Stress-activated protein kinases: activation, regulation and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

21 January 2018

When checkpoints fail

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Mdm2: keeping p53 under control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Checkpoint on the nuclear frontier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The ATM protein is required for sustained activation of NF-kappaB following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Mitotic DNA damage and replication checkpoints in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Chromatin condensation: does histone H1 dephosphorylation play a role?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

ATM: from gene to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Radiation-induced G2 Delay and Spontaneous Chromosome Aberrations in Ataxia-telangiectasia Homozygotes and Heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Interaction between ATM protein and c-Abl in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

NF-kappaB activation: the I kappaB kinase revealed?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Histone acetylation and transcriptional regulatory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Differences in the DNA Supercoiling Response of Irradiated Cell Lines from Ataxia-telangiectasia Versus Unaffected Individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Activation of mammalian gene expression by the UV component of sunlight--from models to reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Cycling, stressed-out and nervous: cellular functions of c-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

IκB kinase: Beginning, not the end

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Reduced telomere length in ataxia-telangiectasia fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Enhanced radiosensitivity by inhibition of nuclear factor kappaB activation in human malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Sites of UV-induced Phosphorylation of the p34 Subunit of Replication Protein A from HeLa Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Radiosensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle delay

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

DNA damage, repair and chromosomal damage

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

The product of the ATM gene is a 370-kDa nuclear phosphoprotein

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

On the nature of a defect in cells from individuals with ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Association of G 1 /S-Phase and Late S-Phase Checkpoints with Regulation of Cyclin-Dependent Kinases in Chinese Hamster Ovary Cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

DNA repair: The Nijmegen breakage syndrome protein

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

DNA damage and cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Determination of cell fate by c-Abl activation in the response to DNA damage

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Mammalian DNA repair responses and genomic instability.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Checkpoints on the road to mitosis

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Alterations in chromosome structure and variations in the inherent radiation sensitivity of human cells.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Regulation of DNA-replication origins during cell-cycle progression

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Cellular responses to DNA damage

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203124

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203124

1 reference

Dimensions Publication ID

29 July 2017

1040621853

0 references

1 reference