Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses (Q33762518)

29 July 2017

title

Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses (English)

1 reference

29 July 2017

3

Jonathan S Dordick

1 reference

29 July 2017

Moo-Yeal Lee

1

1 reference

29 July 2017

Chan Beum Park

series ordinal

2

1 reference

29 July 2017

Douglas S Clark

series ordinal

4

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29 July 2017

language of work or name

English

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publication date

18 January 2005

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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29 July 2017

volume

102

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29 July 2017

issue

4

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29 July 2017

page(s)

983-987

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Phase I and II enzyme characterization of two sources of HepG2 cell lines

29 July 2017

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1 reference

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22 June 2018

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57 varieties: the human cytochromes P450.

22 June 2018

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Acetaminophen-induced hepatotoxicity

22 June 2018

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An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

22 June 2018

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A new hepatoma cell line for toxicity testing at repeated doses

22 June 2018

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Role of ADME characteristics in drug discovery and their in silico evaluation: in silico screening of chemicals for their metabolic stability

22 June 2018

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Hit and lead generation: beyond high-throughput screening

22 June 2018

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Combinatorial compound libraries for drug discovery: an ongoing challenge

22 June 2018

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In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity

22 June 2018

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Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques

22 June 2018

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Bcl-2/bcl-xL bispecific antisense treatment sensitizes breast carcinoma cells to doxorubicin, paclitaxel and cyclophosphamide

22 June 2018

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Clinical proteomics: translating benchside promise into bedside reality

22 June 2018

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Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

22 June 2018

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Microarrays of cells expressing defined cDNAs

22 June 2018

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Screening for human ADME/Tox drug properties in drug discovery

22 June 2018

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The xenobiotic inhibitor profile of cytochrome P4502C8.

22 June 2018

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Bioencapsulation within synthetic polymers (Part 1): sol-gel encapsulated biologicals

22 June 2018

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Human-derived cell lines to study xenobiotic metabolism

22 June 2018

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Protein-bound acrolein: potential markers for oxidative stress

22 June 2018

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Will combinatorial chemistry deliver real medicines?

22 June 2018

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Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.

22 June 2018

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Mechanisms of the Formation and Disposition of Reactive Metabolites That can Cause Acute Liver Injury

22 June 2018

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Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks.

22 June 2018

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Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.

22 June 2018

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Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation

21 January 2018

1 reference

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Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

1 reference

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NADPH-cytochrome P-450 reductase is involved in flunitrazepam reductive metabolism in Hep G2 and Hep 3B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0406755102

Enhanced drug-induced apoptosis associated with P-glycoprotein overexpression is specific to antimicrotubule agents

21 January 2018

1 reference

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Reduction of toxic metabolite formation of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0406755102

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

21 January 2018

1 reference

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Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes

21 January 2018

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Cytotoxicity of cyclophosphamide, paclitaxel, and docetaxel for tumor cell lines in vitro: effects of concentration, time and cytochrome P450-catalyzed metabolism

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A microfabricated array bioreactor for perfused 3D liver culture

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12 December 2020

Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin

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12 December 2020

Organic chemistry in drug discovery

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12 December 2020

Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes

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12 December 2020

High-performance liquid chromatographic determination of acrolein as a marker for cyclophosphamide bioactivation in human liver microsomes

1 reference

12 December 2020

Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells

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12 December 2020

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

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12 December 2020

Cyclophosphamide. Complete inhibition of murine leukemia L1210 in vivo by a Fenton oxidation product

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0406755102

1 reference

29 July 2017

0 references

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29 July 2017

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